Andrographolide: Bioactive Plant Compound for Clarifying, Calming & Functional Skincare Systems

Molecular Identity

• Chemical Name (INCI): Andrographolide
• Molecular Formula: C₂₀H₃₀O₅
• Source: Isolated from the aerial parts of Andrographis paniculata (King of Bitters)

Functional Properties & Use in Formulations

Andrographolide is a labdane-type diterpenoid lactone with multifunctional activity in topical applications. It is gaining traction in advanced cosmetic formulations for its clarifying, soothing, and bio-balancing effects on skin exposed to stress or pollution. Often featured in clean-label and herbally inspired skincare:

• Skin-Calming Potential: Suitable for reducing visible signs of irritation or reactivity
• Clarity Support: Used in complexion-balancing and sebum-regulating emulsions
• Environmental Shielding: Assists in defense against external stressors such as pollution
• Herbal Integration: Compatible with botanical oils, extracts, and emulsifiers

Application formats: light serums, skin-repair systems, anti-fatigue care, sensitive skin lotions, and scalp calming treatments. Supplied in bulk format suitable for lab-scale testing and full production.

Recommended Use Levels

• Skin-calming formulations: 0.05–0.3%
• Balancing and anti-stress emulsions: up to 0.5%
• Rinse-off or scalp systems: 0.1–0.4%

Low water solubility. Disperse in oil phase or use appropriate solubilizers. Formulation pH: 4.5–6.8. Process under low-shear conditions for best active retention.

Material Specifications

• Purity ≥ 98% (HPLC)
• Appearance: Pale yellow to white crystalline powder
• Odor: Mild, herbaceous
• Plant-sourced; vegan and non-GMO

Accompanied by full QA documentation: COA, HPLC, MSDS, microbial & heavy metal test results, residual solvent data, and stability profile.

Regulatory & Compliance Information

• INCI: Andrographolide
• CAS Number: 5508-58-7
• Compliant with EU Cosmetic Regulation
• REACH status: Available upon request

Bulk Ingredient Program – Commercial Advantages

• Consistently high purity material suitable for skin or scalp formulations
• EU-based logistics for efficient delivery across manufacturing sites
• Batch flexibility – available for lab, pilot or full-scale production
• Documentation provided for quality audits and product registration
• Technical support available to assist in formulation design
• Volume pricing models adapted for industrial procurement

Request samples, technical files or bulk quotes for Andrographolide via our commercial team.