Calcium L-5-Methyltetrahydrofolate CAS 151533-22-1 Bulk Supplier | Active Folate Form for Nutraceuticals

Calcium L-5-Methyltetrahydrofolate (CAS 151533-22-1) is the biologically active and stable form of folate, widely used in nutraceutical, pharmaceutical, and food fortification industries. Supplied as a fine white powder with 95–102% assay (HPLC), this calcium salt provides enhanced bioavailability compared to synthetic folic acid, supporting efficient methylation and cellular metabolism.

Product Description

As a reduced, bioactive folate form, Calcium L-5-Methyltetrahydrofolate directly participates in one-carbon metabolism and DNA synthesis without requiring enzymatic conversion. Each production lot undergoes validated HPLC analysis for assay precision and ICP-MS testing for heavy metals, ensuring superior quality and compliance with global standards. Its fine particle size, low bulk density, and neutral sensory profile make it ideal for precise dosing and homogeneous blending in supplements and functional foods.

Technical Properties

• CAS Number: 151533-22-1
• Molecular Formula: C₂₀H₂₃CaN₇O₆
• Molecular Weight: 497.5 g/mol
• Appearance: Fine powder
• Color: White
• Assay (HPLC): 95.0% – 102.0%
• Water Content: 6.0% – 17.0%
• Mesh Size: NLT 90% pass 80 mesh
• Bulk Density: NMT 0.2 g/ml
• Residual Solvents: Ethanol ≤ 5000 ppm, 2-Propanol ≤ 5000 ppm
• Heavy Metals: ≤ 10 ppm (Pb ≤ 2 ppm, As ≤ 1 ppm, Hg ≤ 0.1 ppm, Cd ≤ 1 ppm)
• Microbiology: TPC ≤ 10³ CFU/g, TYMC ≤ 10² CFU/g; E. coli, Salmonella, S. aureus absent

Applications & Industries

Calcium L-5-Methyltetrahydrofolate bulk powder is the preferred folate source in nutritional and medical-grade formulations due to its stability, purity, and direct metabolic activity. It supports next-generation product development across several industries.

• Nutraceuticals: Incorporated into dietary supplements targeting methylation support, homocysteine regulation, and maternal health. It offers superior bioavailability over folic acid and aligns with clean-label supplement trends.
• Pharmaceuticals: Used as an active ingredient in formulations addressing folate deficiency or increased metabolic demand. Its stability and assay precision enable consistent therapeutic dosing.
• Functional Foods & Beverages: Added to fortified products to enhance folate content without altering taste or texture. The calcium salt form ensures compatibility with dry blends and powdered nutrition systems.
• Clinical Nutrition & Research: Utilized in medical food and biochemical research related to methylation pathways, prenatal health, and metabolic balance. Its defined chemical identity ensures reproducible scientific results.

Key Advantages

Superior bioavailability and stability: Unlike synthetic folic acid, Calcium L-5-Methyltetrahydrofolate is a metabolically active folate form readily absorbed and utilized by the body. Its calcium salt form enhances stability against oxidation and degradation.

Pharmaceutical-grade analytical precision: Every batch is validated by HPLC for assay consistency and ICP-MS for trace metal purity. This ensures reproducible performance and compliance with pharmacopeial and nutritional standards.

Formulation-ready physical profile: With a fine particle size and low bulk density, the ingredient disperses uniformly in powders, tablets, and encapsulated systems. It integrates seamlessly into high-precision dosage forms and clean-label product lines.

Regulatory compliance and documentation: Delivered with a full COA, MSDS, and analytical dossier suitable for EU, US, and global regulatory submissions. NST Chemicals guarantees transparent traceability and long-term supply consistency for B2B partners.

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