Lithocholic Acid: Secondary Bile Acid for Lipid-Metabolism & Barrier-Modeling Formulations

Ingredient Identity

• INCI Name: Lithocholic Acid
• Molecular Formula: C₂₄H₄₀O₃
• CAS Number: 434-13-9
• Source: Secondary bile acid produced by intestinal bacteria from chenodeoxycholic acid — provided as a high-purity powder for formulation and research use

Function & Application

Lithocholic Acid is a naturally derived bile acid with a steroidal backbone, instrumental in lipid metabolism and cell signaling. In cosmetic contexts, it can be positioned as a molecular tool for “barrier modeling,” “lipid phase resilience,” and “advanced emulsion architecture.” It’s particularly suited for formula studies exploring skin barrier support, delivery systems, and novel texture stabilizers.

• Facilitates lipid-phase interactions in emulsions and delivery systems
• Utilized in formulation research for barrier and structural modeling
• Relevant in “skin science” and “advanced emulsion” narratives
• Compatible with sterol blends, ceramides, and lipophilic actives
• Ideal for research & development, formulation prototyping, and advanced texture systems

Usage & Handling

• Lipid-phase use: Ideal in oil-rich or emulsified systems — recommended concentration: 0.1–0.5%

Lipid-soluble. Best incorporated within the lipid or oil phase during formulation at moderate temperatures (below 60 °C). Stable across neutral to mildly acidic pH. Handle with care—this bile acid may have cytotoxic properties at elevated levels. Use protective packaging and avoid prolonged heat or direct light exposure.

Technical Specifications

• Purity: ≥ 98% (HPLC)
• Appearance: White to off-white powder
• Molecular Weight: ~376.57 g/mol
• Solubility: Lipid-soluble, minimal aqueous solubility

Quality control includes stringent checks for impurities and consistent purity. Analytical standards such as Certificate of Analysis (COA) are available on request. Bulk supply ensures reproducible quality for pilot-line and industrial research applications.

Regulatory & Safety

• For topical use in experimental and research formulations only — not for human or medical applications
• European cosmetic regulation compliance must be validated per application — not listed as a standard cosmetic active

B2B Supply & Support

• Available via EU warehouse for efficient distribution
• Offers lab, pilot, and industrial-scale packaging
• Technical and formulation support available for development purposes
• Custom pricing and supply terms tailored for research and bulk acquisition

Contact us for pricing, samples, or formulation development inquiries.