D-Mannitol: Versatile Sugar Alcohol for Advanced Biomedical Research
1. Molecular Identity
- Chemical Name: (2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexol
- CAS Number: 69-65-8
- Source: Naturally occurring in various plants and algae; also produced synthetically
2. Biochemical Significance
D-Mannitol is a sugar alcohol with unique properties that make it valuable in both medical and pharmaceutical applications. Its osmotic properties and low reactivity contribute to its diverse uses in research and clinical settings.
3. Key Properties of D-Mannitol
- Osmotic Diuretic: Effectively increases urine output and reduces intracranial pressure
- Excipient: Widely used in pharmaceutical formulations as a bulking agent and sweetener
- Antioxidant: Demonstrates free radical scavenging activity
- Cryoprotectant: Protects cells during freeze-thaw processes
4. Potential Research Applications
- Neurological studies on intracranial pressure management
- Renal function and diuresis investigations
- Pharmaceutical formulation development
- Cryopreservation technique optimization
5. Current Research Focus
Ongoing studies are investigating D-Mannitol’s effects on:
- Traumatic brain injury and cerebral edema
- Acute kidney injury and renal protection
- Enhanced drug delivery systems
- Antioxidant therapies in various disease models
6. Formulation Challenges and Innovations
Researchers are actively working on:
- Developing controlled-release formulations
- Enhancing stability in various pharmaceutical preparations
- Creating novel combinations for synergistic therapeutic effects
7. Regulatory Considerations
D-Mannitol (CAS 69-65-8) is FDA-approved for various medical uses and is Generally Recognized as Safe (GRAS) as a food additive. Its use in specific research applications should comply with relevant regulatory guidelines.
8. Future Research Directions
The scientific community anticipates:
- Advanced studies on neuroprotective mechanisms
- Exploration of D-Mannitol’s potential in targeted drug delivery
- Investigation of its role in managing oxidative stress-related conditions
9. Collaborative Opportunities
We invite neurologists, nephrologists, pharmaceutical scientists, and academic institutions to explore the research potential of D-Mannitol. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at sales@nstchemicals.com.
Join us in advancing biomedical research with D-Mannitol – a versatile sugar alcohol at the forefront of neurological, renal, and pharmaceutical studies.
