Squalene: Essential Triterpene for Advanced Biomedical Research

1. Molecular Identity

• Chemical Name: 2,6,10,15,19,23-Hexamethyltetracosa-2,6,10,14,18,22-hexaene
• CAS Number: 111-02-4
• Source: Found in shark liver oil, olive oil, and various plant sources; also biosynthesized by human sebaceous glands

2. Biochemical Significance

Squalene is a triterpene hydrocarbon with diverse biological functions. Its unique molecular structure serves as a precursor for cholesterol and steroid hormone biosynthesis, making it a compound of significant interest in various fields of research and potential applications.

3. Key Properties of Squalene

• Antioxidant: Exhibits potent free radical scavenging activity
• Skin Penetration Enhancer: Improves transdermal drug delivery
• Emollient: Provides skin moisturizing and softening effects
• Immunostimulant: Shows potential to enhance immune responses

4. Potential Research Applications

• Pharmaceutical formulation development
• Cosmetic and dermatological studies
• Vaccine adjuvant research
• Cardiovascular health investigations

5. Current Research Focus

Ongoing studies are investigating squalene’s effects on:

• Cancer prevention and treatment
• Skin aging and photoprotection
• Lipid metabolism and cholesterol regulation
• Immune system modulation

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing stability and preventing oxidation
• Developing sustainable sources of squalene
• Creating novel drug delivery systems utilizing squalene

7. Regulatory Considerations

Squalene (CAS 111-02-4) is Generally Recognized as Safe (GRAS) by the FDA for use in food and cosmetics. Its use in specific pharmaceutical applications may require additional regulatory approval.

8. Future Research Directions

The scientific community anticipates:

• Advanced studies on squalene’s role in cellular membrane function
• Exploration of its potential in nanotechnology-based drug delivery
• Investigation of squalene’s effects on longevity and age-related diseases

9. Collaborative Opportunities

We invite pharmaceutical researchers, cosmetic scientists, immunologists, and academic institutions to explore the research potential of squalene. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at sales@nstchemicals.com.

Join us in advancing biomedical research with squalene – a versatile triterpene at the intersection of pharmaceutical, cosmetic, and nutritional sciences.