Ursodeoxycholic Acid: Functional Bile Acid for Solubilization, Skin Microbiome Support and Advanced Emulsion Systems

Molecular Identity

• INCI Name: Ursodeoxycholic Acid
• Molecular Formula: C₂₄H₄₀O₄
• Source: Semi-synthetic or microbial-derived secondary bile acid

Functional Use in Cosmetic Formulations

Ursodeoxycholic Acid (UDCA) is a structurally specific bile acid used in dermocosmetic systems for its ability to improve lipid dispersion, influence microbiome balance, and support solubilization of difficult-to-formulate actives. Its amphiphilic nature makes it relevant for use in emulsions, micellar structures, and prebiotic skin treatments.

• Microbiome-Compatible: Often integrated into formulas targeting skin balance and environmental resilience
• Solubilization Agent: Aids in the dispersion of lipophilic ingredients in aqueous or complex systems
• Formulation Stabilizer: Supports emulsion consistency in low-surfactant systems
• Ideal for Dermo-Active Systems: Included in products targeting sensitive or stress-exposed skin

Applied in gel emulsions, microbiome-balancing creams, solubilizing serums, and technical delivery systems. Provided in bulk format for scale-up and R&D use in cosmetic-grade applications.

Typical Usage & Dosage

• Solubilizing or emulsion stabilizer systems: 0.05–0.3%
• Skin microbiota support creams: 0.1–0.5%
• Prebiotic or probiotic-friendly formulas: 0.05–0.2%

Ursodeoxycholic Acid is sparingly soluble in water but dispersible in glycol-based systems. For improved performance, use with co-solubilizers or encapsulation. Optimal pH: 5.0–7.0.

Technical Specifications

• Purity: ≥ 98% (HPLC)
• Appearance: White to off-white crystalline powder
• Odor: Neutral
• Solubility: Low in water; soluble in ethanol, DMSO, PEG

Each batch includes COA, HPLC data, MSDS, microbial profile, solvent residue analysis and heavy metal testing.

Regulatory Compliance

• INCI: Ursodeoxycholic Acid
• CAS Number: 128-13-2
• Cosmetic-grade only; not for oral or pharmaceutical use
• Compliant with EU Cosmetic Regulation (EC) No. 1223/2009
• REACH documentation available upon request

B2B Availability & Technical Support

• Warehouse stock in EU for reliable logistics
• Packaging formats from small-scale to industrial drums
• Batch traceability and full technical file included
• Formulation advice for emulsions, micelles, or skin barrier systems
• Volume-based B2B pricing and framework contracts

Contact us for bulk pricing, regulatory documentation, or formulation integration support for Ursodeoxycholic Acid.