Xanthohumol CAS 6754-58-1 Bulk Supplier | Natural Hop-Derived Chalcone Compound

Xanthohumol (CAS 6754-58-1) is a prenylated flavonoid chalcone extracted from the female flowers of Humulus lupulus L. (hops). Supplied as a brown fine powder with ≥5% purity (HPLC), it is a bioactive compound valued for its antioxidant, stabilizing, and functional properties in nutraceutical, cosmetic, and research formulations.

Product Description

Xanthohumol is a naturally occurring polyphenolic compound belonging to the class of prenylated chalcones. Known for its unique conjugated aromatic structure, it exhibits excellent oxidative stability and compatibility with various natural matrices. Each batch is analyzed for purity by HPLC and verified through ICP-MS for heavy metals and ISO 6579:2002 microbial compliance, ensuring technical-grade consistency and product safety. Its mild sensory profile and botanical origin make it an ideal functional ingredient for plant-based formulations.

Technical Properties

• CAS Number: 6754-58-1
• Molecular Formula: C₂₁H₂₂O₅
• Molecular Weight: 354.4 g/mol
• Plant Origin: Humulus lupulus L. (Hop Flower)
• Appearance: Fine powder
• Color: Brown
• Purity: ≥ 5.0% (HPLC)
• Loss on Drying: ≤ 5.0%
• Sulfated Ash: ≤ 5.0%
• Mesh Size: NLT 95% pass 80 mesh
• Bulk Density: NMT 0.8 g/ml
• Heavy Metals: ≤ 10 ppm (Pb ≤ 2 ppm, As ≤ 1 ppm, Hg ≤ 0.1 ppm, Cd ≤ 1 ppm)
• Microbiology: TPC ≤ 10³ CFU/g, TYMC ≤ 10² CFU/g; E. coli, Salmonella, S. aureus absent

Applications & Industries

Xanthohumol bulk extract is used in nutraceutical, cosmetic, and food-related industries for its antioxidant and stabilizing potential. Its natural hop origin aligns with clean-label and plant-based market trends.

• Nutraceuticals: Incorporated into dietary supplements and functional beverages focused on oxidative balance and metabolic wellness. Its plant-derived antioxidant properties appeal to natural health and longevity formulations.
• Cosmetics: Used in skincare products promoting barrier support, vitality, and “urban defense.” Its polyphenolic structure enhances stability in emulsions and supports anti-aging concepts without synthetic additives.
• Food Industry: Applied as a natural flavor enhancer and preservative component in hop-based or botanical formulations. It contributes subtle aromatic nuances and helps maintain oxidative stability.
• Biochemical Research: Serves as a reference compound in studies of flavonoid biosynthesis, oxidative processes, and metabolic pathways. Its defined purity profile ensures reproducibility across research applications.

Key Advantages

Natural hop-derived bioactive: Extracted from Humulus lupulus flowers, Xanthohumol delivers authentic botanical functionality. Its traceable plant sourcing supports eco-friendly product positioning and sustainability-focused formulations.

Reliable analytical verification: Each batch undergoes HPLC quantification and ICP-MS screening to verify purity and eliminate heavy metal contamination. ISO-certified microbial testing ensures the product meets international safety standards.

Versatile formulation performance: The ingredient’s polyphenolic backbone offers high oxidative stability and compatibility with lipid-based, emulsion, and powder systems. This versatility allows formulators to integrate Xanthohumol across diverse applications efficiently.

Comprehensive documentation and traceability: Supplied with COA, MSDS, and full analytical data package. NST Chemicals provides transparent technical support for regulatory submissions, ensuring smooth integration into nutraceutical and cosmetic product pipelines.

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