Parthenolide: Research-Grade Sesquiterpene Lactone from Natural Sources

1. Molecular Identity

• Chemical Name: (1aR,4E,7aS,10aS,10bS)-1a,5-dimethyl-8-methylene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[2′,3′:9,10]cyclodeca[1,2-b]furan-9(1aH)-one
• CAS Number: 20554-84-1
• Source: Primarily isolated from feverfew (Tanacetum parthenium) and other Asteraceae family plants

2. Biochemical and Research Relevance

Parthenolide is a sesquiterpene lactone with a distinct α-methylene-γ-lactone moiety. Its reactivity with nucleophiles and impact on intracellular signaling make it a key molecule in natural product-based bioactivity studies.

3. Key Characteristics

• Pathway Modulation: Studied for its interaction with NF-κB and oxidative stress pathways
• Bioactivity Target: Applied in cellular assays involving inflammation and redox balance
• Neurobiology Relevance: Investigated in models involving neuroinflammatory markers
• Plant-Derived: Sourced sustainably from botanical extracts

4. Application Areas

• Inflammatory signaling research
• Neurobiology and cellular oxidative stress models
• Natural compound bioactivity screening
• Analytical method development and validation

5. Current Research Topics

Studies involving Parthenolide focus on:

• Cellular redox regulation and NF-κB pathway inhibition
• Mechanistic studies of immune response modulation
• Bioavailability and formulation strategies
• Structure–activity relationship evaluation in analogues

6. Bulk Availability and Specifications

• Form: Solid (≥98% purity, HPLC)
• Usage: For laboratory research use only
• Supply: Bulk quantities available upon request
• Documentation: COA, MSDS, and technical data available

7. Safety and Regulatory Status

Parthenolide (CAS 20554-84-1) is provided exclusively for research and technical applications. This compound is not intended for pharmaceutical, cosmetic, or human consumption purposes.

8. Outlook for Scientific Exploration

Future studies may include:

• Optimization of formulation stability and delivery
• Synergistic research with other plant-derived molecules
• Exploration of Parthenolide in compound libraries and screening platforms

9. Collaborative Opportunities

We invite scientists and technical R&D teams to explore the potential of Parthenolide in laboratory workflows. For product specifications, documentation, or research collaborations, contact us at [email protected].

Advance your natural product research with Parthenolide – a versatile sesquiterpene lactone for modern biochemical investigations.