Chlorogenic Acid: Potent Polyphenol for Advanced Biomedical Research

1. Molecular Identity

• Chemical Name: (1S,3R,4R,5R)-3-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-1,4,5-trihydroxycyclohexanecarboxylic acid
• CAS Number: 327-97-9
• Source: Widely distributed in various plants, particularly abundant in coffee beans and green coffee extract

2. Biochemical Significance

Chlorogenic acid is a polyphenol compound with diverse biological activities. Its unique molecular structure, combining caffeic acid and quinic acid, contributes to its potent antioxidant and potential therapeutic properties, making it a compound of significant interest in nutritional and pharmaceutical research.

3. Key Properties of Chlorogenic Acid

• Antioxidant: Exhibits strong free radical scavenging activity
• Anti-inflammatory: Demonstrates ability to modulate inflammatory responses
• Glucose Metabolism: Shows potential in regulating blood glucose levels
• Hepatoprotective: Indicates promise in protecting liver cells

4. Potential Research Applications

• Metabolic syndrome and diabetes studies
• Cardiovascular health research
• Weight management investigations
• Neuroprotection and cognitive function studies

5. Current Research Focus

Ongoing studies are investigating Chlorogenic acid’s effects on:

• Glucose and lipid metabolism
• Oxidative stress-related disorders
• Liver function and fatty liver disease
• Brain health and neurodegenerative conditions

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing bioavailability and stability
• Developing targeted delivery systems for improved efficacy
• Creating synergistic combinations with other bioactive compounds

7. Regulatory Considerations

Chlorogenic acid (CAS 327-97-9) is Generally Recognized as Safe (GRAS) by the FDA. Its use in specific therapeutic applications may require additional regulatory approval depending on the jurisdiction and intended use.

8. Future Research Directions

The scientific community anticipates:

• Advanced clinical trials for metabolic and cardiovascular indications
• Exploration of Chlorogenic acid’s potential in combination therapies
• Investigation of its role in gut microbiome modulation

9. Collaborative Opportunities

We invite nutritionists, pharmacologists, metabolic researchers, and academic institutions to explore the research potential of Chlorogenic acid. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at [email protected].

Join us in advancing biomedical research with Chlorogenic acid – a powerful polyphenol at the forefront of metabolic and antioxidant studies.