Guaiazulene: Unique Bicyclic Sesquiterpene for Advanced Biomedical Research

1. Molecular Identity

• Chemical Name: 1,4-Dimethyl-7-isopropylazulene
• CAS Number: 489-84-9
• Source: Naturally occurring in various essential oils, particularly from guaiac wood oil

2. Biochemical Significance

Guaiazulene is a bicyclic sesquiterpene with distinctive blue color and diverse biological activities. Its unique molecular structure contributes to its antioxidant, anti-inflammatory, and potential therapeutic properties, making it a compound of significant interest in pharmaceutical and cosmetic research.

3. Key Properties of Guaiazulene

• Antioxidant: Exhibits strong free radical scavenging activity
• Anti-inflammatory: Demonstrates ability to modulate inflammatory responses
• Skin Soothing: Shows potential in alleviating skin irritation
• Chromatic Properties: Possesses a distinctive blue color, useful in formulation indicators

4. Potential Research Applications

• Dermatological studies and skin care formulations
• Anti-inflammatory drug development
• Natural colorant investigations
• Antioxidant research in various biological systems

5. Current Research Focus

Ongoing studies are investigating Guaiazulene’s effects on:

• Skin inflammation and irritation mechanisms
• Oxidative stress in different cellular models
• Potential anticancer properties
• Stability and color retention in various formulations

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing stability in diverse formulation environments
• Developing targeted delivery systems for improved efficacy
• Creating synergistic combinations with other bioactive compounds

7. Regulatory Considerations

Guaiazulene (CAS 489-84-9) is approved for use in cosmetics in many jurisdictions. Its use in specific therapeutic applications would require comprehensive safety and efficacy evaluations to meet regulatory standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced studies on its mechanisms of action in skin health
• Exploration of Guaiazulene’s potential in systemic anti-inflammatory applications
• Investigation of its role in novel drug delivery systems

9. Collaborative Opportunities

We invite dermatologists, pharmacologists, cosmetic scientists, and academic institutions to explore the research potential of Guaiazulene. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at [email protected].

Join us in advancing biomedical and cosmetic research with Guaiazulene – a unique sesquiterpene at the forefront of skin care and anti-inflammatory studies.