Phloretin: Potent Dihydrochalcone for Advanced Biomedical Research

1. Molecular Identity

• Chemical Name: 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
• CAS Number: 60-82-2
• Source: Naturally occurring in apples and apple leaves; also found in other fruits

2. Biochemical Significance

Phloretin is a dihydrochalcone with diverse biological activities. Its unique molecular structure contributes to its potent antioxidant, anti-inflammatory, and potential therapeutic properties, making it a compound of significant interest in nutritional and pharmaceutical research.

3. Key Properties of Phloretin

• Antioxidant: Exhibits strong free radical scavenging activity
• Anti-inflammatory: Demonstrates ability to modulate inflammatory responses
• Glucose Transporter Inhibitor: Shows potential in regulating glucose uptake
• Anticancer Potential: Indicates promise in various cancer models

4. Potential Research Applications

• Diabetes and metabolic syndrome studies
• Cancer research and drug development
• Skin health and photoprotection investigations
• Cardiovascular health studies

5. Current Research Focus

Ongoing studies are investigating Phloretin’s effects on:

• Glucose uptake and insulin sensitivity
• Cancer cell proliferation and apoptosis
• UV-induced skin damage and aging
• Lipid peroxidation and oxidative stress

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing bioavailability and stability
• Developing targeted delivery systems for improved efficacy
• Creating synergistic combinations with other bioactive compounds

7. Regulatory Considerations

Phloretin (CAS 60-82-2) is primarily used in research settings. Its development for specific therapeutic applications would require comprehensive safety and efficacy evaluations to meet regulatory standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced clinical trials for metabolic and dermatological indications
• Exploration of Phloretin’s potential in combination therapies
• Investigation of structure-activity relationships for optimized derivatives

9. Collaborative Opportunities

We invite nutritionists, oncologists, dermatologists, and academic institutions to explore the research potential of Phloretin. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at sales@nstchemicals.com.

Join us in advancing biomedical research with Phloretin – a powerful dihydrochalcone at the forefront of nutritional and pharmaceutical innovations.