What is 4-Demethylepipodophyllotoxin?

4-Demethylepipodophyllotoxin is a natural compound in the polyphenol compound class. It is a compound from a larger epipodophyllotoxin class typically isolated from the American Mayapple plant Podophyllum peltatum.

4-Demethylepipodophyllotoxin and other epidodophyllotoxins are known for their anti-cancer properties. It has been used as a research chemical for direct use and as a starting material for complex derivative synthesis for anti-cancer property evaluation.

4-Demethylepipodophyllotoxin is a microtubule inhibitor preventing their polymerization by binding to the colchicine site.

Derivatives of 4-Demethylepipodophullotoxin have been tested against cancers like testicular cancer, lymphoma, lung cancer, neuroblastoma, leukemia,  and ovarian cancer. 

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