4-Demethylepipodophyllotoxin: High-Purity Natural Lignan for Advanced Research

1. Molecular Identity

• Chemical Name: (5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
• CAS Number: 6559-91-7
• Source: Naturally derived from plants of the Podophyllum genus

2. Biochemical Significance

4-Demethylepipodophyllotoxin is a plant-derived lignan of interest for its well-characterized interaction with DNA-related enzymes and cellular signaling pathways. It plays a key role in natural product research and development of lignan analogues.

3. Key Properties

• DNA Interaction: Studied for its ability to modulate topoisomerase II activity
• Structural Precursor: Used in the synthesis of semi-synthetic lignan derivatives
• Virology Research: Investigated for its potential activity against DNA viruses
• Reference Standard: Useful in purity benchmarking and structure–activity studies

4. Potential Research Applications

• DNA replication and topology studies
• Development of lignan-based reference compounds
• Structure–activity relationship (SAR) analysis
• Exploration of plant secondary metabolite function

5. Current Research Focus

Studies are examining 4-Demethylepipodophyllotoxin in:

• Mechanisms of DNA-interacting compounds
• High-purity lignan precursor optimization
• Synergistic use with other natural products
• Cell culture model systems for enzyme interaction

6. Formulation Challenges and Innovations

Researchers are addressing:

• Solubility enhancement for in vitro applications
• Formulation stability under various laboratory conditions
• Combining with bioactive natural compounds

7. Bulk Availability and Technical Information

• Purity: ≥98% (HPLC)
• Form: Off-white to light yellow crystalline powder
• Packaging: Available in research and bulk quantities
• Documentation: COA, MSDS, and full analytical data available upon request

8. Compliance and Handling

4-Demethylepipodophyllotoxin (CAS 6559-91-7) is supplied for research use only. Not for use in food, cosmetic, or human/animal applications. Proper lab safety procedures must be followed.

9. Future Research Directions

Emerging interest includes:

• Design of new lignan-based scaffolds
• Advanced formulation for cellular assay systems
• Comparative studies with related natural analogues

10. Collaborative Opportunities

We invite natural products researchers, synthetic chemists, and academic institutions to explore the research potential of 4-Demethylepipodophyllotoxin. For bulk pricing, samples, or collaboration inquiries, please contact us at [email protected].

Advance your research with 4-Demethylepipodophyllotoxin – a high-purity natural lignan supporting discovery and innovation in molecular studies.