4-Demethylepipodophyllotoxin: Potent Natural Lignan for Advanced Cancer Research

1. Molecular Identity

• Chemical Name: (5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
• CAS Number: 6559-91-7
• Source: Derived from plants of the Podophyllum genus, particularly Podophyllum peltatum and Podophyllum hexandrum

2. Biochemical Significance

4-Demethylepipodophyllotoxin is a natural lignan with potent biological activities. Its unique molecular structure serves as a precursor for semi-synthetic derivatives with significant anticancer properties, making it a compound of high interest in oncology research and drug development.

3. Key Properties

• Antineoplastic Activity: Demonstrates potent effects against various cancer cell lines
• Topoisomerase II Inhibition: Acts as a potent inhibitor of topoisomerase II enzyme
• Precursor Compound: Serves as a starting material for semi-synthetic anticancer drugs
• Antiviral Potential: Shows activity against certain viral pathogens

4. Potential Research Applications

• Cancer drug development and optimization
• DNA topology and replication studies
• Structure-activity relationship investigations in lignan compounds
• Antiviral research, particularly for DNA viruses

5. Current Research Focus

Ongoing studies are investigating 4-Demethylepipodophyllotoxin’s effects on:

• Various cancer types and mechanisms of action
• Drug-resistant cancer cell lines
• Combination therapies with other anticancer agents
• Novel semi-synthetic derivatives with enhanced properties

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Improving solubility and bioavailability
• Developing targeted delivery systems for enhanced efficacy
• Creating prodrug formulations to optimize pharmacokinetics

7. Regulatory Considerations

As a precursor compound, 4-Demethylepipodophyllotoxin CAS 6559-91-7 is primarily used in research and pharmaceutical manufacturing. Its use in drug production is subject to stringent regulatory oversight to ensure safety and quality.

8. Future Research Directions

The scientific community anticipates:

• Development of new semi-synthetic derivatives with improved therapeutic indices
• Exploration of novel drug delivery systems for podophyllotoxin-based compounds
• Investigation of potential applications beyond cancer treatment

9. Collaborative Opportunities

We invite oncologists, medicinal chemists, pharmacologists, and academic institutions to explore the research potential of 4-Demethylepipodophyllotoxin. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at sales@nstchemicals.com.

Join us in advancing cancer research with 4-Demethylepipodophyllotoxin – a crucial precursor in the development of next-generation antineoplastic agents.