What is 4-Demethylepipodophyllotoxin?
4-Demethylepipodophyllotoxin is a natural compound in the polyphenol compound class. It is a compound from a larger epipodophyllotoxin class typically isolated from the American Mayapple plant Podophyllum peltatum.
4-Demethylepipodophyllotoxin and other epidodophyllotoxins are known for their anti-cancer properties. It has been used as a research chemical for direct use and as a starting material for complex derivative synthesis for anti-cancer property evaluation.
4-Demethylepipodophyllotoxin is a microtubule inhibitor preventing their polymerization by binding to the colchicine site.
Derivatives of 4-Demethylepipodophullotoxin have been tested against cancers like testicular cancer, lymphoma, lung cancer, neuroblastoma, leukemia, and ovarian cancer.
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