7-Ethyl-10-hydroxycamptothecin CAS 86639-52-3

70600

Synonyms: 10-Hydroxy-7-ethylcamptothecin

Download quality specification 7-Ethyl-10-hydroxycamptothecin-CAS-86639-52-3-QS.pdf

500 mg € 70
1 g € 100
2,5 g € 330
5 g € 600
For bulk quantities contact us at [email protected]
Cat. No. NST-10-205
CAS 86639-52-3
Purity 98% (HPLC)
Appearance Light yellow Powder
Molecular formula C22H20N2O5
Molecular weight 392,40
Storage store in a cool & dry place, keep away from strong light and heat

Certificate of analysis available by request to [email protected]

SKU: N/A Categories: ,
Description

7-Ethyl-10-hydroxycamptothecin: Bulk Supply of Potent Topoisomerase I Inhibitor

1. Molecular Identity

  • Chemical Name: (4S)-4-ethyl-4-hydroxy-10-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • CAS Number: 86639-52-3
  • Source: Semi-synthetic compound related to camptothecin analogues

2. Research and Industrial Significance

7-Ethyl-10-hydroxycamptothecin (SN-38) is a well-studied molecule recognized for its strong interaction with topoisomerase I. NST Chemicals offers this compound in bulk quantities for laboratory research, analytical studies, and advanced material development.

3. Key Research Properties

  • Topoisomerase I Interaction: Investigated for strong binding and biological effects
  • Cytotoxicity Profile: Active in a range of cellular research models
  • Metabolic Relevance: Known as a key metabolite of irinotecan in biochemical studies
  • SAR Exploration: Valuable for structure–activity relationship investigations

4. Research Applications

  • Topoisomerase I mechanism studies
  • Metabolic pathway tracing and cellular response models
  • Development of nanoformulations and delivery systems
  • Comparative analysis with other camptothecin derivatives

5. Current Focus Areas

Research includes:

  • Advanced cell line screening and biological evaluation
  • Studies on transport, solubility, and targeting strategies
  • Material compatibility testing in various carrier systems

6. Formulation and Bulk Supply Considerations

  • Solubility Optimization: Preservation of the active lactone form is under evaluation
  • Targeting Systems: Studied for enhanced material specificity
  • Bulk Availability: Supplied in customizable packaging volumes

7. Compliance and Documentation

  • For Research Use Only: Not intended for therapeutic or diagnostic applications
  • Purity and Technical Data: COA and TDS available upon request
  • Standard Handling: Follow safety protocols for laboratory compounds

8. Future Outlook

Further studies will explore:

  • Structural analogues and extended SAR datasets
  • Innovative delivery platforms using SN-38 as a model compound
  • Broader applications in biochemical and materials science

9. Bulk Supply and Collaboration

NST Chemicals offers 7-Ethyl-10-hydroxycamptothecin in bulk quantities with high consistency and technical support. Contact us at [email protected] for specifications, bulk pricing, or collaboration inquiries.

Boost your research capacity with SN-38 – now available in scalable bulk supply for advanced scientific applications.