Artemisinic Acid: Key Intermediate for Research in Natural Product Biosynthesis

1. Molecular Identity

• Chemical Name: (3R,6R,8aS,9R,12S,12aR)-3,6,9-trimethyldecahydro-3,12-epoxypyrano[4,3-j]-1,2-benzodioxepin-10-carboxylic acid
• CAS Number: 80286-58-4
• Source: Derived from Artemisia annua (sweet wormwood) or produced via engineered microorganisms

2. Biochemical Significance

Artemisinic acid is a naturally occurring sesquiterpene and a central biosynthetic intermediate in the production of structurally complex natural products. Due to its unique structure and biogenic role, it is of high interest in biosynthesis, synthetic biology, and natural product research.

3. Key Properties

• Intermediate Compound: Serves as a key molecule in the biosynthetic pathway of bioactive terpenoids
• Research Utility: Studied for its ability to be chemically transformed into diverse analogues
• Biotechnology Relevance: Target molecule in microbial metabolic engineering
• Chemical Versatility: Amenable to functional group modifications

4. Potential Research Applications

• Metabolic pathway analysis and synthetic biology development
• Structure-activity relationship investigations
• Microbial engineering and fermentation studies
• Exploration of broader applications in natural product chemistry

5. Current Research Focus

Ongoing studies are investigating Artemisinic acid’s role in:

• Biotechnological approaches to increase yield in microbial systems
• Development of novel analogues with tailored structural features
• Mechanistic studies related to biosynthetic enzyme functions
• Exploration of additional potential bioactivities in vitro

6. Process Challenges and Innovations

Research efforts are addressing:

• Improving conversion efficiency in chemical transformation steps
• Optimizing biosynthesis in genetically modified organisms
• Developing sustainable and scalable production methods

7. Usage Considerations

Artemisinic acid (CAS 80286-58-4) is intended for laboratory research and industrial synthesis workflows. Any downstream use in regulated industries must comply with applicable guidelines and quality standards.

8. Future Research Directions

Emerging research areas include:

• Bioengineering innovations to enhance production efficiency
• Design of new analogues for use in natural product discovery
• Evaluation of Artemisinic acid derivatives in broader biological models

9. Collaborative Opportunities

We invite researchers, biotech companies, and academic institutions to explore the research potential of Artemisinic acid. For inquiries, collaborations, or to discuss how Artemisinic acid can support your scientific projects, please contact us at [email protected].

Join us in advancing natural compound research with Artemisinic acid – a pivotal molecule in modern biosynthetic and synthetic biology investigations.