Hyodeoxycholic Acid: Unique Bile Acid for Advanced Metabolic Research

1. Molecular Identity

• Chemical Name: 3α,6α-Dihydroxy-5β-cholan-24-oic acid
• CAS Number: 83-49-8
• Source: Naturally occurring secondary bile acid, found in porcine bile and synthesized by intestinal bacteria

2. Biochemical Significance

Hyodeoxycholic acid is a dihydroxy bile acid with unique structural and functional properties. Its distinct molecular configuration contributes to its role in lipid metabolism and potential therapeutic applications, making it a compound of significant interest in hepatic and metabolic research.

3. Key Properties of Hyodeoxycholic Acid

• Lipid Emulsifier: Facilitates dietary fat absorption and cholesterol solubilization
• FXR Modulator: Interacts with the farnesoid X receptor, influencing metabolic pathways
• Hepatoprotective Potential: Demonstrates possible liver-protecting properties
• Cholesterol Metabolism: Plays a role in cholesterol homeostasis

4. Potential Research Applications

• Bile acid signaling studies
• Lipid metabolism investigations
• Hepatic disease research
• Gut microbiome interaction studies

5. Current Research Focus

Ongoing studies are investigating hyodeoxycholic acid’s effects on:

• Non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH)
• Cholestatic liver diseases
• Intestinal barrier function and permeability
• Bile acid-activated receptor signaling pathways

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing stability in various experimental conditions
• Developing targeted delivery systems for improved efficacy
• Creating analogues with optimized pharmacological properties

7. Regulatory Considerations

As a naturally occurring bile acid, hyodeoxycholic acid (CAS 83-49-8) is primarily used in research settings. Its development for therapeutic applications would require comprehensive safety and efficacy evaluations to meet regulatory standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced studies on the role of hyodeoxycholic acid in metabolic diseases
• Exploration of its potential as a biomarker for liver and intestinal disorders
• Investigation of hyodeoxycholic acid-based therapeutics for various conditions

9. Collaborative Opportunities

We invite hepatologists, gastroenterologists, metabolic researchers, and academic institutions to explore the research potential of hyodeoxycholic acid. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at [email protected].

Join us in advancing metabolic and hepatic research with hyodeoxycholic acid – a unique bile acid at the intersection of lipid metabolism and liver health.