Naringin: Potent Flavanone Glycoside for Advanced Biomedical Research

1. Molecular Identity

• Chemical Name: 7-[[2-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
• CAS Number: 10236-47-2
• Source: Naturally occurring in citrus fruits, particularly grapefruit

2. Biochemical Significance

Naringin is a flavanone glycoside with diverse biological activities. Its unique molecular structure contributes to its antioxidant, anti-inflammatory, and potential therapeutic properties, making it a compound of significant interest in nutritional and pharmaceutical research.

3. Key Properties of Naringin

• Antioxidant: Exhibits free radical scavenging activity
• Anti-inflammatory: Demonstrates ability to modulate inflammatory responses
• Cardiovascular Protection: Shows potential in supporting heart health
• Metabolic Modulation: Indicates effects on glucose and lipid metabolism

4. Potential Research Applications

• Cardiovascular disease studies
• Metabolic syndrome and diabetes research
• Cancer prevention investigations
• Neurodegenerative disorder studies

5. Current Research Focus

Ongoing studies are investigating naringin’s effects on:

• Lipid profile and atherosclerosis
• Glucose homeostasis and insulin sensitivity
• Oxidative stress-related cellular damage
• Neuroprotection in various brain disorders

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing bioavailability and absorption
• Developing targeted delivery systems for improved efficacy
• Creating stable formulations for various research applications

7. Regulatory Considerations

Naringin (CAS 10236-47-2) is Generally Recognized as Safe (GRAS) by the FDA for use as a flavoring agent. Its use in specific therapeutic applications would require comprehensive safety and efficacy evaluations to meet regulatory standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced clinical trials for cardiovascular and metabolic indications
• Exploration of naringin’s potential in combination therapies
• Investigation of structure-activity relationships for optimized derivatives

9. Collaborative Opportunities

We invite nutritionists, pharmacologists, and academic institutions to explore the research potential of naringin. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at [email protected].

Join us in advancing biomedical research with naringin – a promising flavanone glycoside at the forefront of natural product-based therapeutic strategies.