Diosmin: Potent Flavonoid Glycoside for Advanced Vascular Research

1. Molecular Identity

• Chemical Name: 7-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
• CAS Number: 520-27-4
• Source: Naturally occurring in citrus fruits, also semi-synthetically produced from hesperidin

2. Biochemical Significance

Diosmin is a flavonoid glycoside with significant vascular protective properties. Its unique molecular structure contributes to its diverse biological activities, making it a compound of considerable interest in pharmaceutical research and potential therapeutic applications.

3. Key Properties of Diosmin

• Venoactive: Enhances venous tone and improves lymphatic drainage
• Anti-inflammatory: Demonstrates ability to modulate inflammatory responses
• Antioxidant: Exhibits free radical scavenging activity
• Microcirculatory Support: Improves capillary resistance and permeability

4. Potential Research Applications

• Chronic venous insufficiency studies
• Hemorrhoid treatment investigations
• Lymphedema research
• Cardiovascular health studies

5. Current Research Focus

Ongoing studies are investigating diosmin’s effects on:

• Venous wall integrity and function
• Inflammatory mediators in vascular disorders
• Oxidative stress in cardiovascular diseases
• Lymphatic system function and edema reduction

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing bioavailability through novel delivery systems
• Developing micronized formulations for improved absorption
• Creating combination therapies with other vascular protective agents

7. Regulatory Considerations

Diosmin (CAS 520-27-4) is approved as a pharmaceutical in several countries for vascular disorders. Its use in research and potential new therapeutic applications may require additional regulatory approval depending on the jurisdiction.

8. Future Research Directions

The scientific community anticipates:

• Advanced clinical trials for various vascular and lymphatic indications
• Exploration of diosmin’s potential in combination with other flavonoids
• Investigation of its effects on microcirculatory disorders in different organs

9. Collaborative Opportunities

We invite vascular researchers, pharmacologists, and academic institutions to explore the research potential of diosmin. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at [email protected].

Join us in advancing vascular research with diosmin – a powerful flavonoid at the forefront of venous and lymphatic health studies.