Phlorizin

Phlorizin is a naturally abundant product that can mainly be found in various fruit trees like apple trees. Phlorizin is a member of the flavonoid O-glycosides compound family – that means that it contains a highly active flavonoid part, that exhibits antioxidative properties, and is linked to glucose moiety that might allow better cell recognition, therefore, improved biological activity.

Scientists have extensively studied Phlorizin and phlorizin supplements for a wide range of biological activities like:

• antihyperglycemic
• antioxidant
• anti-inflammation
• hepatoprotective
• anti-cancer
• antibacterial
• and many more

In the fight against diabetes and obesity

Much scientific research has been done to explore phlorizin for its anti-diabetic properties. Research has concluded that phlorizin can in fact alter several mechanisms to improve conditions of diabetic patients. Phlorizin is able to inhibit glucose uptake by working on specific glucose transporters. This leads to improvement in hyperglycemia without any alterations in insulin secretion. Furthermore, phlorizin is known to inhibit the overexpression of specific enzymes that can lead to abnormal blood glucose levels as well.

Other research has stated that together with an antihyperglycemic effect in diabetics, phlorizin was also able to reduce high lipid levels in the blood resulting in healthier weight regulation in diabetics and non-diabetics as well. Also, phlorizin demonstrated the ability to affect serum lipopolysaccharides which promotes the same positive weight regulatory effects previously discussed.

High antioxidative potential

As phlorizin contains a flavonoid part, it was expected to exhibit high antioxidative potential. Indeed, phlorizin is known to be able to counteract free radicals like reactive oxygen and nitrogen species. that could possibly lead to damage of the skin, DNA, and much more.

Apart from that, phlorizin has also been tested as a potential antioxidant for lipid peroxidation. Such peroxidation can lead to several problems related to fat and lipid accumulation that in some cases could lead to atherosclerosis. Studies have shown the protective effects on low-density lipoproteins and cholesterol and other lipids found in our bodies.

Anti-inflammation effects of Phlorizin

In some studies, there is evidence that suggests high anti-inflammatory properties of Phlorizin. It is able to suppress pro-inflammatory adipokine levels in plasma that prevents the formation of inflammation. Different studies have shown phlorizin’s ability to inhibit nitric oxide synthesis that is responsible for blood vessel dilatation in affected areas preventing swelling. Phlorizin has also shown the ability to decrease levels of cytokines in sunburned skin (UVB damage) and many more.

Other positive effects of Phlorizin

As we mentioned, phlorizin has indeed been widely studied for its biological activity apart from what we have already discussed. There have been several studies that prove Phlorizin’s ability to induce cancer cell death through either direct or indirect pathways. 

Also, antioxidative potential and effects on different metabolic pathways come in handy in possible treatment for bacteria and microorganisms as Phlorizin has been found effective against Staphylococcus aureus and several funai. 

The same antioxidative potential is responsible for cardioprotective effects by keeping blood vessels clean from peroxidation products of healthy lipids. Furthermore, effects on improved bone health and prevention of osteoporosis are in the realm of phlorizin.

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