Liquiritigenin: Unveiling the Potential of a Bioactive Flavanone

1. Molecular Identity

• Chemical Name: 7,4′-Dihydroxyflavanone
• CAS Number: 578-86-9
• Source: Derived from various plants, notably Glycyrrhiza species (licorice)

2. Biochemical Significance

Liquiritigenin is a flavanone with a unique molecular structure that contributes to its diverse biological activities. Its ability to interact with estrogen receptors and modulate various cellular pathways makes it a compound of significant interest in natural product research and potential therapeutic applications.

3. Key Therapeutic Properties

• Phytoestrogen: Demonstrates selective estrogen receptor modulation
• Neuroprotective: Shows promise in protecting neuronal cells
• Anti-inflammatory: Exhibits potential in modulating inflammatory responses
• Antioxidant: Displays free radical scavenging activity

4. Potential Applications

• Women’s health research, particularly menopausal symptoms
• Neurodegenerative disease studies
• Cancer research, especially hormone-dependent cancers
• Inflammatory disorder investigations

5. Current Research Focus

Ongoing studies are investigating Liquiritigenin’s effects on:

• Estrogen receptor-mediated pathways in various tissues
• Neuroprotection in conditions like Alzheimer’s and Parkinson’s diseases
• Breast and prostate cancer cell lines
• Inflammatory signaling cascades

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing bioavailability through novel delivery systems
• Developing targeted formulations for specific tissues
• Creating stable preparations for various research applications

7. Regulatory Considerations

As a naturally derived compound with potential hormonal effects, Liquiritigenin’s (CAS 578-86-9) regulatory status is evolving. Ongoing research aims to establish its safety profile and efficacy for potential therapeutic applications.

8. Future Directions

The scientific community anticipates:

• Advanced clinical trials for specific indications, particularly in women’s health
• Exploration of synergistic effects with other phytoestrogens
• Development of semi-synthetic derivatives with enhanced properties

9. Collaborative Opportunities

We invite researchers, pharmaceutical companies, and academic institutions to explore the research potential of Liquiritigenin. For inquiries, collaborations, or to discuss how Liquiritigenin can benefit your research projects, please contact us at [email protected].

Join us in unlocking the potential of Liquiritigenin – a promising flavanone at the intersection of natural product research and innovative therapeutic strategies.