Nobiletin: Potent Polymethoxylated Flavonoid for Advanced Biomedical Research

1. Molecular Identity

• Chemical Name: 5,6,7,8,3′,4′-Hexamethoxyflavone
• CAS Number: 478-01-3
• Molecular Formula: C21H22O8
• Source: Naturally occurring in citrus fruits, particularly in the peels of tangerines and other mandarin oranges

2. Biochemical Significance

Nobiletin is a polymethoxylated flavonoid with diverse biological activities. Its unique molecular structure contributes to its potent anti-inflammatory, neuroprotective, and potential anticancer properties, making it a compound of significant interest in pharmaceutical research and nutraceutical studies.

3. Key Properties of Nobiletin

• Anti-inflammatory: Demonstrates ability to modulate inflammatory pathways
• Neuroprotective: Shows promise in protecting neuronal cells
• Anticancer: Exhibits potential against various cancer cell lines
• Metabolic Regulation: Indicates efficacy in improving glucose and lipid metabolism

4. Potential Research Applications

• Neurodegenerative disorder studies
• Cancer research and drug development
• Metabolic syndrome and diabetes investigations
• Cardiovascular health research

5. Current Research Focus

Ongoing studies are investigating Nobiletin’s effects on:

• Neuroinflammatory processes in brain disorders
• Cancer cell proliferation and metastasis
• Glucose homeostasis and insulin sensitivity
• Lipid metabolism and atherosclerosis

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing bioavailability through novel delivery systems
• Developing stable formulations for various applications
• Creating synergistic combinations with other bioactive compounds

7. Regulatory Considerations

Nobiletin (CAS 478-01-3) is primarily used in research settings. Its development for specific therapeutic applications would require comprehensive safety and efficacy evaluations to meet regulatory standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced clinical trials for neurodegenerative and metabolic disorders
• Exploration of Nobiletin’s potential in combination cancer therapies
• Investigation of its mechanisms of action at the molecular level

9. Collaborative Opportunities

We invite neurologists, oncologists, endocrinologists, and academic institutions to explore the research potential of Nobiletin. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at [email protected].

Join us in advancing biomedical research with Nobiletin – a powerful polymethoxylated flavonoid at the forefront of natural product-based therapeutic strategies.