What is Diosmetin?
Diosmetin is a flavanoid-type compound with a vast variety of biological activities. It can be found in various sources in nature, but are most natural abundance is in citrus plants like lemon, pompia, orange, tangerine, etc.
Diosmetin has been gathering its use as an anticancer agent, however, it has displayed its ability to be an effective treatment for other diseases like:
- cardiovascular disorders
- cognitive impairment
- and much more.
Diosmetin as an anticancer agent
Medicinal chemists have looked quite extensively to diosmetin as an anticancer agent. It has been employed for the treatment of myeloid leukemia, showed activity against breast, colon, glioma, colorectal, melanoma, and others.
It has been identified that diosmetin can act via various mechanisms to prevent the formation or spread of cancer. Several studies pointed out that in the case of colon, liver cancer cells, diosmetin inhibited cell proliferation. In breast cancer, leukemia, colorectal, and others it induced apoptosis – programmed cell death. Also reduction of cell viability, accumulation of reactive oxygen species, reduction of angiogenesis, and arrest of the cell cycle have been identified.
Some studies have pointed out the positive effect of diosmetin in combination with other anti-cancer drugs. Synergistic effects have been found with paclitaxel in the treatment of lung cancer.
Cardiovascular health improvement with diosmetin
Diosmetin has been studied for its protective effects on our cardiovascular health. Attention has been put on cytoprotective activity on damaged cells caused by myocardial infarct. The use of diosmetin reduced the number of cells where apoptosis was induced. Also, it showed protective effects in ischemic stroke by being involved in several pathways.
Antioxidant activity of diosmetin
Due to their structure, flavonoids have been known for their antioxidative potential. Hydroxyl groups attached to aromatic phenyl moiety are able to neutralize many reactive radicals like reactive oxygen and nitrogen species.
Diosmetin is able to reduce the damage of reactive oxygen species on cell membranes, increase hydroxide as prooxidant concentration, and scavenge reactive metallic cations.
Diosmetin as antimicrobial agent
Medicinal chemists have tested natural product extracts containing diosmetin as the main compound against various pathogenic bacteria. They discovered that diosmetin was effective against Streptococcus pneumonia, Klebsiella pneumonia, Staphylococcus aureus and others.
Diosmetin has been identified to decrease inflammations through several metabolic pathways. It was able to reduce the concentration of inflammation mediators like nitric oxide, tumor necrosis factor, and others.
It was found that diosmetin was an effective treatment against rheumatoid arthritis, neuroinflammation, and neuronal apoptosis, and reduced inflammation in case of acute lung injury.
Improve cognitive impairment
Diosmetin has been evaluated on ethanol-induced cognitive impairment due to anticholinesterase activity. It showed improved spatial memory and even be used in Alzheimer-like cognitive impairment caused by alcohol.
Diosmetin has been studied on several other biological implications, like anti-lipolytic, anti-hemorrhoid, antigout, antiulcer, and gastroprotective activity. This compound has a lot of implications for you to still explore. In order for you to make it easier, visit our store, to acquire high-quality diosmetin now.