Lanosterol: Essential Triterpene for Advanced Sterol Metabolism Research

1. Molecular Identity

• Chemical Name: (3S,5R,10R,13R,14R,17R)-4,4,10,13,14-Pentamethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol
• CAS Number: 79-63-0
• Source: Naturally occurring in animals and yeast; also synthetically produced

2. Biochemical Significance

Lanosterol is a crucial intermediate in sterol biosynthesis, serving as a precursor to cholesterol and other steroids. Its unique molecular structure and role in sterol metabolism make it a compound of significant interest in biochemical, pharmaceutical, and medical research.

3. Key Properties of Lanosterol

• Sterol Precursor: Essential intermediate in cholesterol biosynthesis
• Membrane Component: Contributes to cellular membrane structure and function
• Regulatory Role: Involved in feedback regulation of sterol synthesis
• Potential Therapeutic Agent: Shows promise in cataract prevention and treatment

4. Potential Research Applications

• Cholesterol metabolism studies
• Cataract research and ophthalmological investigations
• Sterol biosynthesis pathway elucidation
• Membrane biology and lipid raft studies

5. Current Research Focus

Ongoing studies are investigating Lanosterol’s effects on:

• Protein aggregation in lens crystallins
• Regulation of cholesterol homeostasis
• Potential anticancer properties
• Interactions with other membrane lipids

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing solubility for various experimental applications
• Developing stable formulations for in vitro and in vivo studies
• Creating targeted delivery systems for ophthalmic applications

7. Regulatory Considerations

Lanosterol (CAS 79-63-0) is primarily used in research settings. Its development for specific therapeutic applications, particularly in ophthalmology, would require comprehensive safety and efficacy evaluations to meet regulatory standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced clinical trials for cataract prevention and treatment
• Exploration of Lanosterol’s potential in other protein aggregation disorders
• Investigation of its role in cellular stress responses

9. Collaborative Opportunities

We invite biochemists, ophthalmologists, pharmacologists, and academic institutions to explore the research potential of Lanosterol. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at [email protected].

Join us in advancing biochemical and medical research with Lanosterol – a key triterpene at the intersection of sterol metabolism and potential therapeutic applications.