Paclitaxel: Microtubule-Stabilizing Diterpenoid for Oncology Research

1. Molecular Identity

• Chemical Name: (2α,4α,5β,7β,10β,13α)-4,10-Bis(acetyloxy)-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• CAS Number: 33069-62-4
• Source: Originally isolated from Taxus brevifolia (Pacific yew); also produced via semi-synthetic processes

2. Research Significance

Paclitaxel is a diterpenoid compound with a unique ability to stabilize microtubules. It plays a key role in cell cycle and mitosis-related studies and is widely investigated in cellular biology and tumor model systems.

3. Core Properties

• Microtubule Stabilization: Promotes polymerization and prevents depolymerization
• Mitotic Arrest: Alters spindle dynamics and inhibits normal mitosis
• Apoptosis Studies: Used in research on programmed cell death mechanisms
• Broad-Spectrum Targeting: Applied in various in vitro tumor models

4. Research Applications

• Cell cycle and mitosis pathway studies
• Investigation of resistance pathways in cellular models
• Targeted delivery and solubility formulation models
• Natural product-based mechanism research

5. Current Research Focus

Paclitaxel continues to be investigated in:

• Hard-to-treat tumor model systems
• Synergistic use with other bioactive agents
• Mechanistic studies on microtubule dynamics
• Nanocarrier and polymer-based formulation innovation

6. Bulk Availability and Technical Data

• Form: Solid, high-purity grade (≥98% HPLC)
• Use: For laboratory and analytical applications
• Documentation: COA and MSDS available on request
• Scale: From milligrams to bulk quantities

7. Handling and Compliance

Paclitaxel (CAS 33069-62-4) is a cytotoxic research compound. It should be handled in accordance with institutional safety protocols for hazardous materials and is not intended for use in humans or animals.

8. Future Directions

• Development of innovative delivery systems
• Structural analog design and synthesis
• Advanced modeling in personalized research settings

9. Collaborative Opportunities

We welcome collaboration with research labs, formulation specialists, and academic teams. For bulk quotes, technical data, or project discussions, please contact us at [email protected].

Advance your oncology-focused research with paclitaxel – a well-characterized compound for in-depth microtubule and mitosis studies.