Ingenol: Harnessing Nature’s Potent Diterpene Compound

1. Molecular Identity

• Chemical Name: (1aR,2S,5R,5aS,6S,8aS,9R,10aS)-5,6,9-trihydroxy-4-methylene-1,1,7,10a-tetramethyl-11-oxo-1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl acetate
• CAS Number: 30220-46-3
• Source: Derived from various Euphorbia species, notably Euphorbia peplus

2. Biochemical Significance

Ingenol is a structurally complex diterpene known for its interaction with protein kinase C (PKC) and involvement in diverse cellular signaling pathways. As a high-value natural product, it is of particular interest in biochemical and molecular research settings.

3. Key Research Properties

• Signal Modulation: Influences intracellular pathways, including PKC activation
• Immunomodulatory: Studied for its effect on immune system responses
• Anti-inflammatory Potential: Modulates key inflammatory signaling cascades
• Antiviral Interest: Explored in virology-related biochemical models

4. Potential Research Applications

• Dermatological compound screening
• Immunology and inflammation-related studies
• Signal transduction and kinase pathway investigations
• Natural product chemistry and semi-synthetic analog development

5. Current Research Focus

Ongoing studies are exploring Ingenol’s behavior in:

• Protein kinase signaling modulation
• Dermatological and cellular inflammation models
• Immunological response regulation
• Latency-related viral activation studies

6. Bulk Supply and Product Specifications

• Form: Crystalline powder
• Purity: ≥98% (HPLC)
• Availability: Bulk supply available upon request
• Intended Use: For laboratory and research use only

7. Technical and Regulatory Notes

Ingenol (CAS 30220-46-3) is a natural compound offered exclusively for R&D and industrial applications. It is not intended for pharmaceutical, cosmetic, or diagnostic use in humans or animals.

8. Future Directions

The research community is focused on:

• Structure-activity relationship studies for new diterpene derivatives
• Designing delivery systems for targeted biochemical pathways
• Understanding Ingenol’s interaction with cellular and immune mechanisms

9. Collaborative Opportunities

We welcome academic labs, industry partners, and bioscience institutions to collaborate on advanced studies involving Ingenol. For technical documentation, quotations, or bulk requests, please contact us at [email protected].

Explore the potential of Ingenol – a research-grade diterpene compound bridging plant biochemistry and cellular signaling innovation.