Veratramine: Complex Natural Alkaloid for Advanced Pharmacological Research

1. Molecular Identity

• Chemical Name: (3β,23R)-14,15,16,17-Tetradehydro-3-hydroxyveratraman-11-one
• CAS Number: 60-70-8
• Source: Isolated from Veratrum species, including V. album and V. viride

2. Scientific Relevance

Veratramine is a plant-derived alkaloid of high structural complexity, widely studied for its effects on cardiovascular physiology and ion transport mechanisms. Its ability to modulate sodium channels and influence developmental processes makes it a key compound for pharmacological and toxicological research.

3. Key Research Properties

• Hypotensive Potential: Investigated for its role in reducing blood pressure
• Ion Channel Interaction: Modulates sodium currents in neuronal and cardiac tissues
• Developmental Impact: Explored for its embryotoxic effects in developmental models (for research use only)
• Unique Molecular Scaffold: Contains multiple functional groups and a rigid polycyclic structure

4. Research Applications

• Cardiovascular and electrophysiological studies
• Ion channel and action potential modulation
• Developmental biology and teratogenicity research
• Natural product chemistry and structure-function analysis

5. Current Research Focus

Active investigations include:

• Veratramine’s mechanisms in vasodilation and blood pressure modulation
• Its role in sodium channel activity and signal conduction
• Experimental embryology and developmental disruption modeling
• Preliminary screening for cytotoxic or anticancer activities

6. Formulation and Analytical Development

• Targeted delivery system design to improve selectivity
• Stability optimization for storage and assay compatibility
• SAR (structure-activity relationship) modeling for future compound development

7. Regulatory and Safety Notes

Veratramine (CAS 60-70-8) is intended strictly for laboratory and analytical research use. Due to its biological potency and teratogenicity in experimental models, appropriate safety precautions are required. Not intended for human or veterinary applications.

8. Future Outlook

Researchers are exploring:

• Refined mechanistic studies in cardiovascular and neuropharmacology
• Design of synthetic analogues with favorable safety profiles
• Elucidation of ecological and botanical roles in plant systems

9. Research Support and Bulk Availability

NST Chemicals offers Veratramine in research-grade quality with full documentation. Bulk quantities and technical support are available upon request. For collaboration, product inquiries, or regulatory support, please contact us at [email protected].

Advance your pharmacological studies with Veratramine – a structurally distinct plant alkaloid supporting modern research in ion channel function, blood pressure regulation, and developmental biology.