Macranthoidin B: Novel Triterpenoid Saponin for Advanced Phytochemical Research

1. Molecular Identity

• Chemical Name: 3-O-{β-D-Glucopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→3)]-α-L-arabinopyranosyl}-oleanolic acid 28-O-β-D-glucopyranosyl ester
• CAS Number: 136849-88-2
• Source: Isolated from Lonicera macranthoides, a species of honeysuckle

2. Biochemical Significance

Macranthoidin B is a complex triterpenoid saponin with a unique molecular structure. Its presence in Lonicera species and potential biological activities make it a compound of significant interest in natural product research, pharmacognosy, and potential therapeutic applications.

3. Key Properties

• Structural Complexity: Features an oleanolic acid core with multiple sugar moieties
• Biological Potential: Demonstrates various pharmacological activities in preliminary studies
• Natural Product: Offers insights into plant secondary metabolism
• Phytochemical Marker: Useful for quality control of Lonicera macranthoides extracts

4. Potential Research Applications

• Natural product chemistry and structural elucidation studies
• Pharmacological screening for various biological activities
• Traditional Chinese Medicine (TCM) research
• Structure-activity relationship investigations of triterpenoid saponins

5. Current Research Focus

Ongoing studies are investigating Macranthoidin B’s potential in:

• Anti-inflammatory and immunomodulatory activities
• Anticancer properties and mechanisms of action
• Antiviral effects, particularly against influenza viruses
• Synergistic effects with other natural compounds

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Developing efficient extraction and purification methods
• Enhancing stability and bioavailability for potential formulations
• Creating semi-synthetic derivatives with optimized properties

7. Regulatory Considerations

As a naturally occurring compound, Macranthoidin B (CAS 136849-88-2) is primarily used in research settings. Any potential therapeutic applications would require comprehensive safety and efficacy evaluations to meet regulatory standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced studies on the pharmacokinetics and pharmacodynamics of Macranthoidin B
• Exploration of its potential in combination with conventional therapies
• Investigation of its ecological role in plant defense mechanisms

9. Collaborative Opportunities

We invite natural product chemists, pharmacologists, TCM researchers, and academic institutions to explore the research potential of Macranthoidin B. For inquiries, collaborations, or to discuss how Macranthoidin B can benefit your research projects, please contact us at [email protected].

Join us in unlocking the full potential of Macranthoidin B – a complex triterpenoid saponin at the forefront of phytochemical research and drug discovery.