Lathyrol: Versatile Diterpenoid for Advanced Biochemical Research

1. Molecular Identity

• Chemical Name: (4R,5S,6R,9S,11R,12R,13S,14R)-4,12,13,14-tetrahydroxy-3,7-dimethyl-1-methylenetetracyclo[9.3.0.0²,⁴.0⁶,⁸]tetradec-7-en-5-yl acetate
• CAS Number: 34420-19-4
• Source: Isolated from various Euphorbia species, particularly Euphorbia lathyris

2. Biochemical Significance

Lathyrol is a macrocyclic diterpenoid with a unique molecular structure that contributes to its diverse biological activities. Its presence in Euphorbia species and potential pharmacological properties make it a compound of significant interest in natural product research and potential therapeutic applications.

3. Key Properties

• Structural Complexity: Features a tetracyclic core with multiple functional groups
• Biological Activity: Demonstrates potential in various pharmacological areas
• Natural Product: Offers insights into plant secondary metabolism
• Synthetic Target: Presents challenges and opportunities in total synthesis

4. Potential Research Applications

• Natural product chemistry and biosynthesis studies
• Structure-activity relationship investigations
• Medicinal chemistry and drug discovery
• Plant biology and phytochemical research

5. Current Research Focus

Ongoing studies are investigating Lathyrol’s potential in:

• Anti-inflammatory and immunomodulatory activities
• Anticancer properties and mechanisms of action
• Synthetic methodology development
• Ecological roles in plant-environment interactions

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Developing efficient extraction and purification methods
• Creating semi-synthetic derivatives with enhanced properties
• Exploring biotechnological approaches for sustainable production

7. Regulatory Considerations

As a naturally occurring compound, Lathyrol (CAS 34420-19-4) is primarily used in research settings. Any potential therapeutic applications would require comprehensive safety and efficacy evaluations to meet regulatory standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced studies on the biological mechanisms of Lathyrol and its derivatives
• Exploration of potential pharmaceutical applications
• Development of total synthetic routes for Lathyrol and related compounds

9. Collaborative Opportunities

We invite natural product chemists, medicinal chemists, pharmacologists, and academic institutions to explore the research potential of Lathyrol. For inquiries, collaborations, or to discuss how Lathyrol can benefit your research projects, please contact us at [email protected].

Join us in unlocking the full potential of Lathyrol – a complex diterpenoid at the forefront of natural product research and drug discovery.