Madecassic Acid (CAS 18449-41-7): Botanical Triterpenoid for Research and Advanced Formulation

1. Molecular Identity

• Chemical Name: (2α,3β,4α,6β,20α,23S)-2,3,6,23-tetrahydroxyurs-12-en-28-oic acid
• CAS Number: 18449-41-7
• Source: Primarily isolated from Centella asiatica

2. Scientific Significance

Madecassic acid is a pentacyclic triterpenoid commonly found in traditional botanical extracts. Its complex molecular profile and presence in natural formulations make it a focus of ongoing investigation in dermal, neurological, and antioxidant research models.

3. Researched Characteristics

• Skin System Studies: Evaluated in models of matrix support and structure
• Inflammatory Pathways: Included in screening for biochemical modulation
• Neuronal Models: Assessed for role in oxidative and structural stability
• Antioxidant Behavior: Explored in free radical response assays

4. Areas of Research Application

• Skin-focused formulation and dermal system research
• Natural product screening in inflammation-related models
• Neuroscience investigations and cellular stress evaluations
• Functional ingredient inclusion in botanical complex systems

5. Ongoing Investigation Themes

• Skin barrier interaction and matrix behavior
• Cellular pathway evaluation under stress conditions
• Model-based studies of neuronal support and phytocompound synergy
• Biochemical screening of antioxidant activity

6. Formulation and Development Considerations

• Delivery Solutions: Investigated in both topical and advanced carrier systems
• Stability and Compatibility: Studied for integration in skin-focused products
• Bioavailability Enhancement: A target for ongoing formulation research

7. Use Guidelines and Regulatory Notes

• Intended Use: For research and industrial formulation development only
• Documentation: COA and specification sheets available upon request
• Regulatory Status: Varies by jurisdiction and intended application; evaluation required for therapeutic claims

8. Future Research Pathways

• Structure–function analysis in advanced delivery formats
• Exploration of phytocomplex synergy within Centella asiatica extracts
• Development of semi-synthetic analogues for research use

9. Collaborative Inquiries

NST Chemicals supplies high-purity Madecassic acid (CAS 18449-41-7) for scientific and industrial R&D. To request bulk pricing, formulation support, or collaborative discussion, please contact [email protected].

Explore the advanced research potential of Madecassic acid – a refined natural triterpenoid supporting innovation in botanical and skin science applications.