Magnolol: Potent Biphenyl Neolignan for Advanced Biomedical Research

1. Molecular Identity

• Chemical Name: 4-Allyl-2-(5-allyl-2-hydroxyphenyl)phenol
• CAS Number: 528-43-8
• Molecular Formula: C18H18O2
• Source: Naturally occurring in the bark of Magnolia officinalis and other Magnolia species

2. Biochemical Significance

Magnolol is a biphenyl neolignan with diverse biological activities. Its unique molecular structure contributes to its potent antioxidant, anti-inflammatory, and neuroprotective properties, making it a compound of significant interest in pharmaceutical research and traditional medicine studies.

3. Key Properties of Magnolol

• Antioxidant: Exhibits strong free radical scavenging ability
• Anti-inflammatory: Demonstrates potential to modulate inflammatory pathways
• Neuroprotective: Shows promise in protecting neuronal cells
• Anxiolytic: Indicates efficacy in reducing anxiety-like behaviors

4. Potential Research Applications

• Neurodegenerative disorder studies
• Anxiety and depression research
• Cancer investigations
• Cardiovascular health studies

5. Current Research Focus

Ongoing studies are investigating Magnolol’s effects on:

• Neuroinflammatory processes in brain disorders
• GABA receptor modulation and anxiolytic effects
• Cancer cell proliferation and apoptosis pathways
• Vascular smooth muscle cell function

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing bioavailability through novel delivery systems
• Developing stable formulations for various applications
• Creating synergistic combinations with other bioactive compounds

7. Regulatory Considerations

Magnolol (CAS 528-43-8) is primarily used in research settings and traditional medicine. Its development for specific therapeutic applications would require comprehensive safety and efficacy evaluations to meet regulatory standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced clinical trials for neurodegenerative and anxiety disorders
• Exploration of Magnolol’s potential in combination cancer therapies
• Investigation of its mechanisms of action at the molecular level

9. Collaborative Opportunities

We invite neurologists, psychiatrists, oncologists, and academic institutions to explore the research potential of Magnolol. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at [email protected].

Join us in advancing biomedical research with Magnolol – a powerful biphenyl neolignan at the forefront of natural product-based therapeutic strategies.