Podophyllotoxin: Potent Natural Lignan for Advanced Biomedical Research

1. Molecular Identity

• Chemical Name: (5R,5aR,8aR,9R)-5,8,8a,9-Tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
• CAS Number: 518-28-5
• Source: Naturally occurring in Podophyllum species, especially Podophyllum peltatum (American Mayapple)

2. Biochemical Significance

Podophyllotoxin is a highly bioactive lignan, known for its strong interaction with microtubule dynamics and cell cycle regulation. Its unique structure makes it a valuable compound in oncology-related studies and virology research.

3. Key Properties of Podophyllotoxin

• Mitotic Inhibition: Disrupts microtubule assembly, arresting cell division
• Cytotoxic Effects: Demonstrates efficacy in various cellular models
• Antiviral Activity: Studied for its effect on viral replication mechanisms
• Topical Use Potential: Investigated for treatment of skin conditions

4. Potential Research Applications

• Mechanistic studies in cell cycle regulation
• Evaluation of antiviral compounds for skin-related viral infections
• Model compound in lignan biosynthesis and structure-activity studies
• Investigation of cytotoxicity in multi-resistant cell lines

5. Current Research Focus

Ongoing studies focus on:

• Modulating signaling pathways in mitosis and apoptosis
• Evaluation of Podophyllotoxin-based analogues
• Topical applications for dermatological models
• Structure-function relationships of lignan derivatives

6. Formulation Challenges and Innovations

Researchers are addressing:

• Improving solubility and bioavailability in vitro
• Reducing off-target cytotoxic effects
• Designing stable delivery systems for controlled release

7. Bulk Availability and Technical Data

• Form: High-purity crystalline solid (≥98% HPLC)
• Packaging: Research and industrial-scale bulk quantities available
• Intended Use: For scientific research and laboratory analysis
• Documentation: COA, MSDS, and specification sheet available upon request

8. Compliance and Handling

Podophyllotoxin (CAS 518-28-5) is intended for research use only. Proper laboratory safety procedures and institutional handling guidelines must be followed.

9. Future Research Directions

Scientific developments are exploring:

• Podophyllotoxin analogues with improved selectivity and reduced toxicity
• Applications in combination with other cytotoxic agents
• Advanced in vitro models for antiviral and mitotic inhibition research

10. Collaborative Opportunities

We invite oncology researchers, molecular biologists, virologists, and institutional partners to explore the potential of Podophyllotoxin in their research. For custom orders or bulk inquiries, please contact us at [email protected].

Partner with us to expand research possibilities using Podophyllotoxin – a powerful plant-derived lignan at the frontier of cellular and antiviral studies.