Tabersonine: Indole Alkaloid for Advanced Research and Bulk Supply

1. Molecular Identity

• Chemical Name: (2R,3R,7aS,14bR,15S)-3-ethenyl-1,2,3,4,5,6,7,7a-octahydro-15-methyl-12H-indolo[2,3-a]quinolizine
• CAS Number: 4429-63-4
• Source: Extracted from Voacanga africana and various Tabernaemontana species

2. Scientific Relevance

Tabersonine is a naturally occurring indole alkaloid with a complex molecular scaffold. It plays a key role as a biosynthetic precursor in plant-derived alkaloid pathways and is widely studied in natural product chemistry for its potential biological properties.

3. Key Features

• Biosynthetic Intermediate: Precursor in the formation of structurally related alkaloids such as vindoline
• Exploratory Bioactivity: Evaluated in various in vitro models
• Natural Origin: Isolated from plant genera used in ethnobotanical traditions
• Neurochemical Interest: Investigated for interaction with CNS pathways

4. Research Applications

• Natural product biosynthesis studies
• Alkaloid pathway elucidation
• Neuroactive compound screening
• Exploratory antimicrobial models

5. Current Research Focus

Recent studies investigate tabersonine in:

• Plant alkaloid metabolic routes
• Structural analog design and synthesis
• Interaction with neuronal receptors and enzymatic targets
• Development of bio-based reference compounds

6. Bulk Supply and Technical Challenges

• Bulk Availability: Offered in gram to kilogram quantities for laboratory and industrial research
• Purification: Isolation and crystallization methods continue to evolve
• Stability: Stored under dry, controlled conditions for optimal shelf life

7. Regulatory Note

Tabersonine (CAS 4429-63-4) is supplied strictly for research and development use. It is not intended for human consumption, therapeutic use, or inclusion in finished products without proper regulatory approval.

8. Future Perspectives

Ongoing and upcoming directions include:

• Synthetic pathway modeling and engineering
• Functional group modification for derivative optimization
• Cross-species comparison of biosynthetic expression

9. Contact and Collaboration

NST Chemicals offers Tabersonine in bulk for research and analytical purposes. For quotations, technical specifications, or R&D collaborations, please contact us at [email protected].

Explore the scientific value of Tabersonine – a unique alkaloid supporting the advancement of botanical and biosynthetic research.