Vincamine: Potent Alkaloid for Advanced Neuropharmacological Research

1. Molecular Identity

• Chemical Name: (3α,14α,16α)-14,15-dihydro-14-hydroxyeburnamenine-14-carboxylic acid methyl ester
• CAS Number: 1617-90-9
• Source: Extracted from Vinca minor (lesser periwinkle) or synthetically produced

2. Biochemical Significance

Vincamine (1617-90-9) is an indole alkaloid with significant effects on cerebral metabolism. Its unique molecular structure contributes to its vasodilatory and neuroprotective properties, making it a compound of considerable interest in neuropharmacological research and potential therapeutic applications.

3. Key Properties of Vincamine

• Cerebral Vasodilator: Enhances blood flow to the brain
• Neuroprotective: Demonstrates potential in protecting neuronal cells
• Cognitive Enhancer: Shows promise in improving memory and cognitive function
• Antihypoxic: Exhibits protective effects against cerebral hypoxia

4. Potential Research Applications

• Cognitive disorder studies
• Cerebrovascular disease investigations
• Neuroprotection research
• Memory enhancement studies

5. Current Research Focus

Ongoing studies are investigating vincamine’s effects on:

• Age-related cognitive decline
• Cerebral circulation disorders
• Neurodegenerative diseases
• Ischemic stroke models

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing bioavailability and blood-brain barrier penetration
• Developing sustained-release formulations
• Creating novel drug delivery systems for targeted cerebral action

7. Regulatory Considerations

Vincamine (CAS 1617-90-9) is approved as a prescription drug in several countries for cerebrovascular disorders. Its use in research and potential new therapeutic applications may require additional regulatory approval depending on the jurisdiction.

8. Future Research Directions

The scientific community anticipates:

• Advanced clinical trials for specific neurological indications
• Exploration of vincamine’s potential in combination therapies
• Investigation of long-term effects on brain health and cognition

9. Collaborative Opportunities

We invite neuropharmacologists, cognitive scientists, and academic institutions to explore the research potential of vincamine. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at [email protected].

Join us in advancing neuropharmacological research with vincamine – a powerful alkaloid at the forefront of cognitive enhancement and neuroprotection studies.