10-Deacetylbaccatin III: Strategic Intermediate for Taxane Research

1. Molecular Identity

• Chemical Name: (2α,4α,5β,7β,10β,13α)-4,10-Dihydroxy-13-{[(2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• CAS Number: 32981-86-5
• Source: Extracted from Taxus species, particularly Taxus baccata (European yew)

2. Scientific Relevance

10-Deacetylbaccatin III is a highly valuable natural product in taxane chemistry. It serves as a key intermediate in semi-synthetic pathways and supports the development of structurally complex taxane analogues. Its multifunctional core makes it ideal for structure–activity relationship (SAR) investigations and synthetic diversification.

3. Key Research Properties

• Taxane Intermediate: Central scaffold for advanced taxane analogues
• Defined Stereochemistry: Facilitates targeted semi-synthetic modifications
• Biological Research Tool: Explored for its intrinsic cellular activity
• Sustainable Sourcing: Enables more efficient use of yew biomass

4. Potential Research Applications

• Semi-synthetic transformation of natural taxanes
• Advanced studies on taxane SAR and scaffold engineering
• Investigation of taxane pathway biosynthesis and biocatalysis
• Process optimization in natural product production systems

5. Current Research Topics

Research groups are actively exploring:

• Novel routes to paclitaxel analogues using 10-DAB III
• Enzymatic and chemoenzymatic conversions of taxanes
• Enhanced yield strategies for semi-synthetic production
• Biochemical behavior of modified taxane frameworks

6. Process and Formulation Considerations

Ongoing innovations include:

• Improved extraction and purification techniques
• Development of scalable synthetic workflows
• Evaluation of taxane solubility and carrier systems for lab use

7. Compliance and Usage Context

10-Deacetylbaccatin III (CAS 32981-86-5) is widely used as a research-grade intermediate in biochemical synthesis and process development. For use in regulated applications, compliance with applicable manufacturing and handling standards is required.

8. Future Research Opportunities

Emerging directions include:

• Design of novel taxane-inspired compounds for broader research use
• Greener synthesis pathways through biotechnological approaches
• Expanding taxane applications beyond oncology-focused studies

9. Collaborative Opportunities

We invite medicinal chemists, natural product researchers, synthetic biologists, and academic partners to explore the potential of 10-Deacetylbaccatin III. For technical specifications or research collaboration inquiries, contact us at [email protected].

Unlock the potential of 10-Deacetylbaccatin III – a vital scaffold in modern taxane research and a bridge between natural sources and synthetic innovation.