Geniposide: Unlocking the Potential of a Versatile Iridoid Glycoside

1. Molecular Identity

• Chemical Name: Methyl (1S,4aS,7aS)-7-(hydroxymethyl)-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate
• CAS Number: 24512-63-8
• Source: Primarily extracted from the fruit of Gardenia jasminoides Ellis

2. Biochemical Significance

Geniposide is an iridoid glycoside with a unique molecular structure that contributes to its diverse pharmacological activities. Its ability to modulate various cellular pathways has made it a compound of significant interest in natural product research and potential therapeutic applications.

3. Key Therapeutic Properties

• Neuroprotective: Shows promise in protecting neuronal cells
• Anti-inflammatory: Demonstrates ability to modulate inflammatory responses
• Hepatoprotective: Exhibits potential in protecting liver cells
• Antidiabetic: Indicates promise in regulating glucose metabolism

4. Potential Applications

• Neurodegenerative disease research
• Inflammatory disorder studies
• Liver disease investigations
• Diabetes and metabolic syndrome research

5. Current Research Focus

Ongoing studies are investigating Geniposide’s effects on:

• Alzheimer’s and Parkinson’s diseases
• Chronic inflammatory conditions
• Non-alcoholic fatty liver disease
• Type 2 diabetes and insulin resistance

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing bioavailability through novel delivery systems
• Developing targeted formulations for specific tissues
• Creating stable preparations for various research applications

7. Regulatory Considerations

As a naturally derived compound, Geniposide’s (CAS 24512-63-8) regulatory status is evolving. Its use in specific therapeutic applications would require comprehensive safety and efficacy evaluations to meet regulatory standards.

8. Future Directions

The scientific community anticipates:

• Advanced clinical trials for specific health indications
• Exploration of Geniposide’s potential in combination therapies
• Development of semi-synthetic derivatives with enhanced properties

9. Collaborative Opportunities

We invite researchers, pharmaceutical companies, and academic institutions to explore the therapeutic potential of Geniposide. For inquiries, collaborations, or to discuss how Geniposide can benefit your research or product development, please contact us at [email protected].

Join us in unlocking the full potential of Geniposide – a promising natural compound at the forefront of neurodegenerative, metabolic, and inflammatory research.