Andrographolide: Potent Diterpenoid Lactone for Advanced Biomedical Research

1. Molecular Identity

• Chemical Name: 3α,14,15,18-tetrahydroxy-5β,9βH,10α-labda-8(20),12-dien-16-oic acid γ-lactone
• CAS Number: 5508-58-7
• Source: Isolated from Andrographis paniculata, also known as “King of Bitters”

2. Biochemical Significance

Andrographolide is a labdane diterpenoid with diverse biological activities. Its unique molecular structure contributes to its potent anti-inflammatory, immunomodulatory, and potential therapeutic properties, making it a compound of significant interest in pharmaceutical research and traditional medicine studies.

3. Key Properties of Andrographolide

• Anti-inflammatory: Exhibits strong ability to modulate inflammatory pathways
• Immunomodulatory: Demonstrates potential to regulate immune responses
• Hepatoprotective: Shows promise in protecting liver cells
• Anticancer Potential: Indicates efficacy against various cancer cell lines

4. Potential Research Applications

• Inflammatory disorder studies
• Immune system modulation research
• Liver disease investigations
• Cancer research and drug development

5. Current Research Focus

Ongoing studies are investigating Andrographolide’s effects on:

• Various inflammatory signaling pathways
• Autoimmune conditions and immune regulation
• Hepatic fibrosis and liver function
• Different cancer types and mechanisms of action

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing bioavailability through novel delivery systems
• Developing stable formulations for various applications
• Creating semi-synthetic derivatives with improved pharmacological profiles

7. Regulatory Considerations

Andrographolide (CAS 5508-58-7) is primarily used in research settings and traditional medicine. Its development for specific therapeutic applications would require comprehensive safety and efficacy evaluations to meet regulatory standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced clinical trials for inflammatory and liver disorders
• Exploration of Andrographolide’s potential in combination therapies
• Investigation of its mechanisms of action at the molecular level

9. Collaborative Opportunities

We invite immunologists, hepatologists, oncologists, and academic institutions to explore the research potential of Andrographolide. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at sales@nstchemicals.com.

Join us in advancing biomedical research with Andrographolide – a powerful diterpenoid lactone at the forefront of natural product-based therapeutic strategies.