Andrographolide: Potent Diterpenoid Lactone for Advanced Biomedical Research

1. Molecular Identity

• Chemical Name: 3α,14,15,18-tetrahydroxy-5β,9βH,10α-labda-8(20),12-dien-16-oic acid γ-lactone
• CAS Number: 5508-58-7
• Source: Isolated from Andrographis paniculata, commonly known as “King of Bitters”

2. Biochemical Significance

Andrographolide is a labdane diterpenoid known for its wide-ranging biological properties. Its unique molecular structure supports strong anti-inflammatory and immune-modulating activities, and it is actively studied in traditional medicine and modern natural product research.

3. Key Properties of Andrographolide

• Anti-inflammatory: Influences key inflammation-related pathways
• Immunomodulatory: Supports immune response balance
• Hepatoprotective: Demonstrates protective effects on liver cells
• Cellular Regulation: Under investigation for effects on abnormal cell behavior

4. Potential Research Applications

• Studies on chronic inflammation and immune challenges
• Liver health and cellular function research
• Cell growth regulation and apoptosis models
• Complementary pathways in botanical extract studies

5. Current Research Focus

• Regulation of inflammation in cellular and in vivo models
• Supportive potential in immune function balance
• Liver metabolism and protection under stress conditions
• Molecular-level studies in oxidative and metabolic pathways

6. Formulation Challenges and Innovations

• Improving solubility and stability in lab settings
• Structural optimization for enhanced consistency in test systems
• Evaluation of semi-synthetic analogs for expanded applications

7. Regulatory Considerations

Andrographolide (CAS 5508-58-7) is intended for scientific research and industrial analysis. Usage outside of research contexts may require additional evaluation according to local regulations.

8. Future Research Directions

• Advanced studies on inflammation, metabolism, and liver-related functions
• Combination research with other plant-derived compounds
• Detailed investigations of molecular interactions and mechanisms

9. Collaborative Opportunities

We invite researchers in immunology, hepatology, oncology, and related fields to explore the scientific potential of Andrographolide. For bulk orders, cooperation opportunities, or to learn more, contact us at [email protected].

Discover how Andrographolide can support your natural compound research – available now in bulk quantities for analytical and experimental use.