Camptothecin: High-Purity Alkaloid for Topoisomerase and DNA Research

1. Molecular Identity

• Chemical Name: (S)-4-Ethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• CAS Number: 7689-03-4
• Source: Isolated from *Camptotheca acuminata* and available via synthetic production

2. Biochemical Significance

Camptothecin is a naturally occurring alkaloid known for its ability to interact with DNA topoisomerase I. Its structure and activity make it a widely studied reference compound in molecular biology, enzymology, and DNA topology research.

3. Key Properties

• Topoisomerase I Interaction: Interferes with DNA relaxation during replication
• Cell Cycle Specificity: Activity linked to S-phase processes
• Molecular Scaffold: Basis for developing novel molecular probes
• Reference Standard: Frequently used in mechanistic and screening assays

4. Potential Research Applications

• Studies of DNA damage and repair pathways
• Research on replication stress and genomic stability
• Evaluation of topoisomerase-related cellular responses
• Structure-activity relationship exploration in natural products

5. Current Research Focus

Current studies examine Camptothecin’s:

• Mechanistic role in topoisomerase inhibition
• Effects on DNA strand breakage and repair dynamics
• Use in combinatorial biochemical assays
• Improved delivery methods for laboratory systems

6. Formulation and Stability Research

Ongoing efforts are focused on:

• Enhancing solubility and shelf stability
• Encapsulation methods for controlled delivery in research models
• Structural modifications for advanced analog screening

7. Bulk Availability and Specifications

• Purity: ≥98% (HPLC)
• Form: Yellow to pale orange crystalline powder
• Availability: Supplied in standard and bulk research quantities
• Supporting Documents: COA, MSDS, HPLC chromatogram

8. Handling and Intended Use

Camptothecin (CAS 7689-03-4) is supplied strictly for laboratory research, analytical reference, and industrial R&D. It is not intended for use in humans or animals. Use only under qualified supervision in appropriate laboratory environments.

9. Future Research Perspectives

Researchers are exploring:

• Design of new analogues for topoisomerase interaction studies
• Combination protocols for cellular pathway screening
• Use as a control compound in DNA stability assays

10. Collaboration and Supply

We invite research institutions, molecular biologists, and synthetic chemists to explore Camptothecin’s potential in your projects. For quotations, bulk pricing, or technical support, please contact us at [email protected].

Advance your research in DNA dynamics and natural product chemistry with Camptothecin – a precision alkaloid for topoisomerase-focused innovation.