Tetrandrine: Potent Bisbenzylisoquinoline Alkaloid for Advanced Biomedical Research

1. Molecular Identity

• Chemical Name: 6,6′,7,12-Tetramethoxy-2,2′-dimethylberbaman
• CAS Number: 518-34-3
• Source: Naturally occurring in Stephania tetrandra, a Chinese medicinal herb

2. Biochemical Significance

Tetrandrine is a bisbenzylisoquinoline alkaloid with diverse pharmacological activities. Its unique molecular structure contributes to its potential anti-inflammatory, antitumor, and calcium channel blocking properties, making it a compound of significant interest in pharmaceutical research and traditional medicine studies.

3. Key Properties of Tetrandrine

• Calcium Channel Blocker: Demonstrates ability to inhibit calcium influx
• Anti-inflammatory: Shows potential in modulating inflammatory pathways
• Antitumor: Exhibits promise in inhibiting various cancer cell lines
• Immunomodulatory: Indicates efficacy in regulating immune responses

4. Potential Research Applications

• Cancer research and drug development
• Cardiovascular disease studies
• Autoimmune disorder investigations
• Neuroprotection and neurodegenerative disease research

5. Current Research Focus

Ongoing studies are investigating Tetrandrine’s effects on:

• Various cancer types and their molecular pathways
• Calcium signaling in cardiac and smooth muscle cells
• Inflammatory mediators and cytokine production
• Neuroprotective mechanisms in brain disorders

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing bioavailability through novel delivery systems
• Developing targeted formulations for specific disease conditions
• Creating synergistic combinations with other therapeutic agents

7. Regulatory Considerations

Tetrandrine (CAS 518-34-3) is primarily used in research settings. Its development for specific therapeutic applications would require comprehensive safety and efficacy evaluations to meet regulatory standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced clinical trials for cancer and cardiovascular disorders
• Exploration of Tetrandrine’s potential in combination therapies
• Investigation of its mechanisms of action at the molecular level

9. Collaborative Opportunities

We invite oncologists, cardiologists, immunologists, and academic institutions to explore the research potential of Tetrandrine. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at [email protected].

Join us in advancing biomedical research with Tetrandrine – a powerful bisbenzylisoquinoline alkaloid at the forefront of natural product-based therapeutic strategies.