Limonin: Potent Limonoid for Advanced Biomedical Research

1. Molecular Identity

• Chemical Name: (4R,4aS,6aR,7R,8S,10R,11S)-7-Hydroxy-3,7,11-trimethyl-13-oxo-4,4a,5,6,6a,7,8,9,10,11,12,13b-dodecahydro-4,8-methanobenzo[2,3]cyclobutyl[3,4]cyclopenta[1,2-c]pyran-1-carboxylic acid
• CAS Number: 1180-71-8
• Molecular Formula: C26H30O8
• Source: Naturally occurring in citrus fruits, particularly in seeds and peels

2. Biochemical Significance

Limonin is a limonoid with diverse biological activities. Its unique molecular structure contributes to its potential anticancer, antioxidant, and anti-inflammatory properties, making it a compound of significant interest in pharmaceutical research and nutraceutical studies.

3. Key Properties of Limonin

• Anticancer: Demonstrates potential against various cancer cell lines
• Antioxidant: Exhibits free radical scavenging capabilities
• Anti-inflammatory: Shows promise in modulating inflammatory responses
• Antimicrobial: Indicates efficacy against certain pathogens

4. Potential Research Applications

• Cancer research and drug development
• Oxidative stress and aging studies
• Inflammatory disorder investigations
• Antimicrobial and food preservation research

5. Current Research Focus

Ongoing studies are investigating Limonin’s effects on:

• Cancer cell apoptosis and cell cycle regulation
• Antioxidant enzyme activities and oxidative stress markers
• Inflammatory signaling pathways in various tissues
• Bacterial growth inhibition mechanisms

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing bioavailability through novel delivery systems
• Developing stable formulations for various applications
• Creating synergistic combinations with other bioactive compounds

7. Regulatory Considerations

Limonin (1180-71-8) is primarily used in research settings and as a component in some dietary supplements. Its development for specific therapeutic applications would require comprehensive safety and efficacy evaluations to meet regulatory standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced clinical trials for cancer prevention and treatment
• Exploration of Limonin’s potential in combination therapies
• Investigation of its long-term effects on health and disease prevention

9. Collaborative Opportunities

We invite oncologists, nutritionists, pharmacologists, and academic institutions to explore the research potential of Limonin. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at [email protected].

Join us in advancing biomedical research with Limonin – a powerful limonoid at the forefront of natural product-based therapeutic strategies.