Celastrol: Research-Grade Triterpenoid for Advanced Applications

1. Molecular Identity

• Chemical Name: (3β,4α,10β)-4,4-Dimethyl-1-oxo-3-phenoxymethyl-1,2,3,4,5,6,7,10-octahydro-7,10-epoxynaphtho[2,3-c]pyran
• CAS Number: 34157-83-0
• Source: Extracted from Tripterygium wilfordii (Thunder God Vine) and other Celastraceae species

2. Biochemical and Technical Significance

Celastrol is a pentacyclic triterpenoid compound known for its robust biological profile in experimental model systems. Its complex structure supports wide interest in academic and industrial R&D related to inflammation, oxidative stress, and cellular homeostasis.

3. Key Properties

• Inflammation pathway modulation: Engages NF-κB and other markers in vitro
• Neuroprotective mechanisms: Explored in oxidative and stress-related models
• Cellular heat shock response: Influences HSF1 activation
• Redox balance: Investigated in metabolic pathways

4. Application Areas

• Academic and technical research on inflammation
• Exploratory studies on cellular stress and protection
• Model systems for metabolic regulation
• R&D in bioactive triterpenoid synthesis

5. Current Research Focus

Ongoing investigations examine Celastrol’s relevance in:

• Redox-sensitive pathways and stress protein modulation
• Rheological properties in inflammation assays
• Neurodegenerative model system applications
• Regulation of metabolic markers in vitro

6. Bulk Supply and Material Specifications

• Form: Powder (research-grade, ≥98% HPLC)
• Use: For laboratory research and industrial applications only
• Availability: Bulk quantities and technical documentation available on request
• Storage: Store in a cool, dry environment protected from light

7. Compliance and Handling

Celastrol (CAS 34157-83-0) is intended strictly for research use. Not for human or veterinary applications. Proper laboratory protocols and safety measures should be followed when handling this material.

8. Research Outlook

Future directions include:

• Semi-synthetic derivatives and structure-activity optimization
• Use in stress signaling and heat shock model studies
• Biotechnological applications in natural product screening

9. Collaboration and Contact

We supply Celastrol in bulk to research institutions, laboratories, and industrial developers. For quotations, COA, or collaboration discussions, contact us at [email protected].

Advance your research with Celastrol – a potent triterpenoid compound bridging natural origin and modern innovation.