Celastrol: Potent Triterpene for Advanced Biomedical Research

1. Molecular Identity

• Chemical Name: (3β,4α,10β)-4,4-Dimethyl-1-oxo-3-phenoxymethyl-1,2,3,4,5,6,7,10-octahydro-7,10-epoxynaphtho[2,3-c]pyran
• CAS Number: 34157-83-0
• Source: Extracted from Tripterygium wilfordii (Thunder God Vine) and other Celastraceae plants

2. Biochemical Significance

Celastrol is a pentacyclic triterpenoid with a unique molecular structure that contributes to its diverse and potent biological activities. Its presence in traditional Chinese medicine and its multifaceted effects make it a compound of significant interest in drug discovery and various fields of biomedical research.

3. Key Properties

• Anti-inflammatory: Exhibits potent inhibition of NF-κB and other inflammatory pathways
• Anticancer Potential: Demonstrates effects on multiple cancer-related targets
• Neuroprotective: Shows promise in neurodegenerative disease models
• Heat Shock Response Modulator: Activates heat shock factor 1 (HSF1)

4. Potential Research Applications

• Cancer research and drug development
• Autoimmune and inflammatory disorder studies
• Neurodegenerative disease investigations
• Obesity and metabolic syndrome research

5. Current Research Focus

Ongoing studies are investigating Celastrol’s effects on:

• Various cancer types and mechanisms of action
• Chronic inflammatory conditions such as rheumatoid arthritis
• Alzheimer’s and Parkinson’s disease models
• Leptin sensitivity and obesity-related pathways

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing bioavailability and reducing toxicity
• Developing targeted delivery systems for improved efficacy
• Creating synergistic combinations with other bioactive compounds

7. Regulatory Considerations

As a potent bioactive compound, Celastrol (CAS 34157-83-0) is primarily used in research settings. Its development for therapeutic applications would require extensive safety and efficacy evaluations to meet regulatory standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced preclinical and potential clinical trials for specific indications
• Exploration of Celastrol’s potential in combination therapies
• Development of synthetic analogues with improved safety profiles

9. Collaborative Opportunities

We invite cancer researchers, immunologists, neuroscientists, and academic institutions to explore the research potential of Celastrol. For inquiries, collaborations, or to discuss how Celastrol can benefit your research projects, please contact us at sales@nstchemicals.com.

Join us in advancing biomedical research with Celastrol – a powerful triterpene at the forefront of innovative therapeutic strategies.