Cephalomannine: Potent Taxane for Advanced Cancer Research

1. Molecular Identity

• Chemical Name: (2α,4α,5β,7β,10β,13α)-4,10-bis(acetyloxy)-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• CAS Number: 71610-00-9
• Source: Isolated from various Taxus species, particularly Taxus wallichiana

2. Biochemical Significance

Cephalomannine is a naturally occurring taxane, structurally similar to paclitaxel (Taxol). Its unique molecular structure contributes to its potent antimitotic and anticancer properties, making it a compound of significant interest in cancer research and drug development.

3. Key Properties

• Antimitotic Activity: Disrupts microtubule dynamics, inhibiting cell division
• Anticancer Potential: Demonstrates cytotoxicity against various cancer cell lines
• Structural Similarity to Paclitaxel: Offers insights into structure-activity relationships
• Natural Source: Provides an alternative taxane for research and potential drug development

4. Potential Research Applications

• Cancer drug development and optimization
• Comparative studies with other taxanes
• Investigation of microtubule dynamics and cell cycle regulation
• Exploration of synergistic effects with other anticancer agents

5. Current Research Focus

Ongoing studies are investigating Cephalomannine’s effects on:

• Various cancer types and mechanisms of action
• Drug resistance in cancer cells
• Combination therapies with established anticancer drugs
• Structure-activity relationships in taxane compounds

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing solubility and bioavailability
• Developing targeted delivery systems for improved efficacy
• Creating semi-synthetic derivatives with optimized properties

7. Regulatory Considerations

As a naturally occurring taxane, Cephalomannine (CAS 71610-00-9) is primarily used in research settings. Its development for therapeutic applications would require extensive safety and efficacy evaluations to meet regulatory standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced preclinical studies comparing Cephalomannine to other taxanes
• Exploration of Cephalomannine’s potential in overcoming taxane resistance
• Development of novel Cephalomannine-based anticancer formulations

9. Collaborative Opportunities

We invite cancer researchers, medicinal chemists, pharmaceutical scientists, and academic institutions to explore the research potential of Cephalomannine. For inquiries, collaborations, or to discuss how Cephalomannine can benefit your research projects, please contact us at [email protected].

Join us in advancing cancer research with Cephalomannine – a promising taxane compound in the ongoing development of effective anticancer therapies.