Cephalomannine: Natural Taxane for Advanced Cell Biology Research

1. Molecular Identity

• Chemical Name: (2α,4α,5β,7β,10β,13α)-4,10-bis(acetyloxy)-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• CAS Number: 71610-00-9
• Source: Naturally derived from Taxus species, including Taxus wallichiana

2. Research Significance

Cephalomannine is a taxane compound structurally related to other natural taxanes. Its distinctive structure contributes to microtubule interaction and makes it valuable in cellular biology, biochemical analysis, and structure-activity investigations.

3. Key Properties

• Microtubule Binding: Known to influence cytoskeletal dynamics
• Cell Division Studies: Useful for in vitro evaluation of mitotic processes
• Taxane Framework: A model compound for taxane-related structural exploration
• Natural Origin: Extracted from plant sources for scientific applications

4. Application Areas

• Comparative taxane analysis and SAR studies
• Microtubule-targeting compound evaluation
• Cell cycle and cytoskeleton-related research
• Interaction profiling with bioactive molecules

5. Ongoing Scientific Interest

Research groups are currently exploring:

• Cephalomannine’s role in tubulin binding and polymerization assays
• Mechanistic insights into taxane-mediated mitotic arrest
• Structure-based optimization of taxane analogues
• Model use in resistance mechanism exploration

6. Formulation Considerations

Active investigation includes:

• Solubility optimization for experimental protocols
• Carrier systems for in vitro delivery
• Structural tuning for enhanced analytical compatibility

7. Compliance and Handling

• Research-Grade Material: Cephalomannine (CAS 71610-00-9) is intended for laboratory and scientific use only
• Documentation: Technical specifications and data sheets available
• Safe Use: Handle under standard laboratory safety guidelines

8. Future Research Directions

Potential focus areas include:

• Structure-based refinement of natural taxanes
• Cell-based screening for functional analogs
• Development of taxane-inspired reference materials

9. Collaboration Opportunities

We invite researchers, academic labs, and scientific institutions to explore Cephalomannine’s role in microtubule-focused research. For specifications, availability, or collaboration inquiries, contact us at [email protected].

Contribute to cytoskeleton and microtubule research with Cephalomannine – a structurally distinct taxane for in vitro scientific studies.