Cyclovirobuxine D: Potent Alkaloid from Traditional Chinese Medicine

1. Molecular Identity

• Chemical Name: (3β,5α,16α,20S)-4,4,14-Trimethyl-3,20-bis(methylamino)pregnan-16-ol
• CAS Number: 860-79-7
• Source: Isolated from Buxus microphylla, a plant used in Traditional Chinese Medicine

2. Biochemical Significance

Cyclovirobuxine D is a steroidal alkaloid with a unique molecular structure that contributes to its diverse pharmacological activities. Its presence in traditional remedies and its potential therapeutic effects make it a compound of significant interest in natural product research and drug discovery.

3. Key Properties

• Cardiovascular Effects: Demonstrates potential in improving heart function
• Anti-arrhythmic Activity: Shows promise in regulating heart rhythm
• Anti-inflammatory: Exhibits ability to modulate inflammatory responses
• Neuroprotective Potential: Indicates possible benefits in neurological conditions

4. Potential Research Applications

• Cardiovascular disease studies
• Arrhythmia research and drug development
• Inflammatory disorder investigations
• Neurodegenerative disease research

5. Current Research Focus

Ongoing studies are investigating Cyclovirobuxine D’s effects on:

• Cardiac ion channels and electrophysiology
• Inflammatory signaling pathways
• Neuroprotection mechanisms in brain cells
• Potential synergistic effects with other natural compounds

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing bioavailability and stability
• Developing targeted delivery systems for improved efficacy
• Creating semi-synthetic derivatives with optimized properties

7. Regulatory Considerations

As a compound derived from Traditional Chinese Medicine, Cyclovirobuxine D (CAS 60-79-7) is primarily used in research settings. Its development for therapeutic applications would require extensive safety and efficacy evaluations to meet regulatory standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced preclinical studies for specific cardiovascular indications
• Exploration of Cyclovirobuxine D’s potential in combination therapies
• Investigation of structure-activity relationships for novel analogues

9. Collaborative Opportunities

We invite researchers, pharmaceutical companies, and academic institutions to explore the research potential of Cyclovirobuxine D. For inquiries, collaborations, or to discuss how Cyclovirobuxine D can benefit your research projects, please contact us at [email protected].

Join us in unlocking the full potential of Cyclovirobuxine D – a promising alkaloid at the intersection of traditional medicine and modern pharmacological research.