Madecassoside: Unlocking the Potential of a Potent Centella Glycoside

1. Molecular Identity

• Chemical Name: (2α,3β,4α,6β,20α,23S)-2,3,6,23-tetrahydroxyurs-12-en-28-oic acid 2-O-α-L-rhamnopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside
• CAS Number: 34540-22-2
• Source: Primarily isolated from Centella asiatica (Gotu kola)

2. Biochemical Significance

Madecassoside is a triterpene glycoside recognized as a major constituent of Centella asiatica. Its sugar-linked pentacyclic structure is widely studied for its role in skin physiology, cellular protection, and formulation science.

3. Key Research Properties

• Skin Repair: Supports collagen synthesis and tissue regeneration
• Soothing Effect: Reduces visible signs of inflammation
• Antioxidant: Acts as a free radical scavenger
• Neuroprotective Interest: Explored in cognitive wellness research

4. Potential Applications

• Cosmeceutical innovation and advanced skincare formulations
• Skin recovery and barrier support research
• Botanical anti-aging ingredient development
• Neuroscience-related natural product studies

5. Current Research Focus

Studies on Madecassoside are currently exploring:

• Topical effects on skin renewal and barrier integrity
• Role in oxidative stress protection at the cellular level
• Interaction with inflammatory pathways
• Neuronal health and botanical formulation strategies

6. Bulk Supply and Technical Profile

• Purity: ≥95% (HPLC)
• Form: Fine powder
• Packaging: Available in bulk quantities
• Use: For R&D and industrial applications only

7. Safety and Compliance

Madecassoside (CAS 34540-22-2) is a plant-derived compound with a favorable safety profile in topical and cosmetic applications. All uses must comply with local regulatory guidelines. Not intended for pharmaceutical or clinical use in humans or animals.

8. Innovation Outlook

Ongoing exploration includes:

• Stabilized formulations for enhanced skin penetration
• Synergistic blends with other Centella constituents
• Advanced delivery methods for cosmetic or laboratory use

9. Collaborative Opportunities

We welcome partnerships with cosmetic developers, biotech innovators, and research institutions. For bulk quotes, formulation support, or collaboration inquiries, contact us at [email protected].

Discover the versatility of Madecassoside – a plant-derived compound bridging traditional knowledge with modern formulation science.