Jervine (CAS 469-59-0): Unique Natural Alkaloid for Signal Pathway and Developmental Research

1. Molecular Identity

• Chemical Name: (3β,23R)-17,23-Epoxy-3-hydroxyveratraman-11-one
• CAS Number: 469-59-0
• Source: Isolated from Veratrum species, notably Veratrum californicum

2. Scientific Relevance

Jervine is a structurally complex natural alkaloid known for its inhibition of the Hedgehog signaling pathway. This unique biological mechanism has made it a reference compound in developmental biology, pathway modulation studies, and cellular differentiation models.

3. Key Research Properties

• Hedgehog Pathway Modulation: Investigated in cellular signaling and growth regulation studies
• Embryonic Development: Used in experimental models of teratogenicity and morphogenesis
• Anti-inflammatory Potential: Explored for effects on cytokine and inflammatory markers
• Antifungal Activity: Tested in biological screens against fungal targets

4. Research Applications

• Signal transduction and developmental research
• Models of abnormal cellular growth and morphology
• Studies in inflammation and cytokine regulation
• Natural product antifungal screening

5. Current Areas of Study

Ongoing research includes:

• Hedgehog-associated signaling disruptions
• Teratogenic pathways and embryogenesis models
• Mechanistic investigation in inflammation
• Biological selectivity in fungal assays

6. Technical Specifications and Supply

• Purity: ≥98% (HPLC)
• Form: Crystalline solid
• Availability: Bulk and research-scale quantities available
• Use: For research and analytical purposes only

7. Safety and Handling

Jervine is for laboratory research only. Due to its potent biological activity, it must be handled with appropriate protective procedures. Not for human or veterinary use.

8. Future Research Outlook

Scientists are exploring:

• Development of research analogues with reduced toxicity
• Structure-activity relationships for targeted biological effects
• Hedgehog pathway modulation in various disease models

9. Partner With Us

NST Chemicals welcomes collaboration with universities, biotech developers, and pharmaceutical researchers. For product data, regulatory documentation, or bulk pricing, contact us at [email protected].

Advance your research with Jervine – a natural alkaloid supporting key discoveries in signal transduction and developmental biology.