Jervine: Exploring the Potential of a Potent Steroidal Alkaloid

1. Molecular Identity

• Chemical Name: (3β,23R)-17,23-Epoxy-3-hydroxyveratraman-11-one
• CAS Number: 469-59-0
• Source: Isolated from various Veratrum species, particularly Veratrum californicum

2. Biochemical Significance

Jervine is a complex steroidal alkaloid with a unique molecular structure that contributes to its potent biological activities. It is known for its ability to inhibit the Hedgehog signaling pathway, making it a compound of significant interest in developmental biology and cancer research.

3. Key Therapeutic Properties

• Anticancer: Demonstrates potential in inhibiting Hedgehog-dependent cancers
• Teratogenic: Influences embryonic development (research use only)
• Anti-inflammatory: Shows promise in modulating inflammatory responses
• Antifungal: Exhibits activity against certain fungal species

4. Potential Applications

• Cancer therapy research, particularly for Hedgehog-driven cancers
• Developmental biology studies
• Investigation of inflammatory pathways
• Antifungal drug development

5. Current Research Focus

Ongoing studies are investigating Jervine’s effects on:

• Various cancer types, especially basal cell carcinoma and medulloblastoma
• Embryonic development and congenital disorders (for research purposes)
• Inflammatory signaling pathways
• Fungal infections resistant to conventional treatments

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing bioavailability and targeted delivery
• Developing analogs with improved safety profiles
• Creating stable formulations for research applications

7. Regulatory Considerations

Due to its potent biological effects, Jervine (CAS 469-59-0) is primarily used in research settings. Strict regulations govern its use, particularly due to its teratogenic potential. Any therapeutic applications would require extensive safety evaluations.

8. Future Directions

The scientific community anticipates:

• Development of Jervine-inspired compounds with enhanced anticancer properties
• Further elucidation of Hedgehog pathway modulation in various diseases
• Exploration of Jervine’s potential in combination therapies

9. Collaborative Opportunities

We invite researchers, pharmaceutical companies, and academic institutions to explore the research potential of Jervine. For inquiries, collaborations, or to discuss how Jervine can benefit your research projects, please contact us at [email protected].

Join us in unlocking the potential of Jervine – a powerful steroidal alkaloid at the forefront of cancer research and developmental biology studies.