Piperine: Potent Alkaloid for Advanced Biomedical Research

1. Molecular Identity

• Chemical Name: (2E,4E)-1-[1,3-benzodioxol-5-yl]-5-(3,4-methylenedioxyphenyl)-2,4-pentadiene-1-one
• CAS Number: 94-62-2
• Source: Naturally occurring in black pepper (Piper nigrum) and long pepper (Piper longum)

2. Biochemical Significance

Piperine is an alkaloid with diverse biological activities. Its unique molecular structure contributes to its potential bioavailability-enhancing, anti-inflammatory, and thermogenic properties, making it a compound of significant interest in pharmaceutical research, nutrition studies, and drug development.

3. Key Properties of Piperine

• Bioavailability Enhancer: Demonstrates ability to increase absorption of various nutrients and drugs
• Anti-inflammatory: Shows potential to modulate inflammatory pathways
• Thermogenic: Exhibits promise in enhancing metabolism and energy expenditure
• Antioxidant: Indicates free radical scavenging capabilities

4. Potential Research Applications

• Drug absorption and bioavailability studies
• Metabolic disorder and obesity research
• Inflammatory condition investigations
• Neurodegenerative disease studies

5. Current Research Focus

Ongoing studies are investigating Piperine’s effects on:

• Enhancement of drug and nutrient absorption mechanisms
• Metabolic pathways related to thermogenesis and fat metabolism
• Inflammatory signaling cascades in various tissues
• Neuroprotective mechanisms in brain disorders

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Developing novel delivery systems to optimize Piperine’s bioavailability-enhancing effects
• Creating stable formulations for various applications
• Exploring synergistic combinations with other bioactive compounds

7. Regulatory Considerations

Piperine (CAS 94-62-2) is used in research settings and as a component in some dietary supplements. Its development for specific therapeutic applications would require comprehensive safety and efficacy evaluations to meet regulatory standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced clinical trials for bioavailability enhancement of various drugs
• Exploration of Piperine’s potential in metabolic and neurological disorders
• Investigation of its long-term effects on nutrient absorption and metabolism

9. Collaborative Opportunities

We invite pharmacologists, nutritionists, neurologists, and academic institutions to explore the research potential of Piperine. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at [email protected].

Join us in advancing biomedical research with Piperine – a powerful alkaloid at the forefront of bioavailability enhancement and natural product-based therapeutic strategies.