Piroctone Olamine: Advanced Antifungal Agent for Dermatological Research

1. Molecular Identity

• Chemical Name: 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone, compound with 2-aminoethanol (1:1)
• CAS Number: 68890-66-4
• Source: Synthetically produced antifungal compound

2. Biochemical Significance

Piroctone olamine is a hydroxypyridone antifungal agent, known for its effectiveness against various fungi and yeasts. Its unique mechanism of action and broad spectrum of activity make it a compound of significant interest in dermatological research and personal care product development.

3. Key Properties

• Antifungal Activity: Effective against a wide range of fungi, including Malassezia species
• Metal Chelation: Forms complexes with metal ions, disrupting fungal cellular processes
• Low Systemic Absorption: Primarily acts on the skin surface, minimizing systemic effects
• Compatibility: Well-tolerated in various formulations

4. Potential Research Applications

• Dandruff and seborrheic dermatitis studies
• Antifungal formulation development
• Scalp microbiome research
• Personal care product innovation

5. Current Research Focus

Ongoing studies are investigating Piroctone olamine’s effects on:

• Mechanisms of action against various fungal species
• Synergistic effects with other antifungal agents
• Long-term efficacy and safety in topical applications
• Impact on the balance of skin microflora

6. Formulation Challenges and Innovations

Researchers and formulators are actively working on:

• Enhancing stability in diverse formulation types
• Developing controlled-release systems for prolonged activity
• Creating novel combinations with other active ingredients

7. Regulatory Considerations

Piroctone olamine (CAS 68890-66-4) is approved for use in cosmetic and personal care products in many countries. Its use in specific therapeutic applications may require additional regulatory approval depending on the jurisdiction and intended use.

8. Future Research Directions

The scientific community anticipates:

• Advanced studies on the impact of Piroctone olamine on skin microbiome
• Exploration of potential applications beyond scalp and skin care
• Development of new delivery systems for enhanced efficacy

9. Collaborative Opportunities

We invite dermatologists, cosmetic scientists, microbiologists, and academic institutions to explore the research potential of Piroctone olamine. For inquiries, collaborations, or to discuss how Piroctone olamine can benefit your research projects, please contact us at [email protected].

Join us in advancing dermatological research and personal care innovation with Piroctone olamine – a key player in the fight against fungal skin conditions.