Cholic Acid: Essential Bile Acid for Biological Research

1. Molecular Identity

• Chemical Name: 3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid
• CAS Number: 81-25-4
• Source: Primary bile acid naturally produced in the liver from cholesterol

2. Biochemical Significance

Cholic Acid is a primary bile acid crucial for lipid metabolism and absorption. Its amphipathic nature and role in cholesterol homeostasis make it a compound of significant interest in various fields of biological and medical research.

3. Key Research Properties

• Lipid Emulsification: Facilitates dietary fat absorption
• Cholesterol Regulation: Plays a key role in cholesterol metabolism
• Signaling Molecule: Acts as a signaling agent in various physiological processes
• Pharmaceutical Excipient: Used in drug formulations to enhance bioavailability

4. Potential Research Applications

• Lipid metabolism and absorption studies
• Bile acid signaling pathway investigations
• Pharmaceutical formulation development
• Cholesterol homeostasis research

5. Current Research Focus

Ongoing studies are investigating Cholic Acid’s effects on:

• Metabolic disorders, including obesity and diabetes
• Liver diseases and bile acid-related pathologies
• Gut microbiome interactions and influence
• Novel drug delivery systems utilizing bile acid transporters

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Developing Cholic Acid derivatives for enhanced therapeutic effects
• Creating stable formulations for various research applications
• Optimizing Cholic Acid-based drug delivery systems

7. Regulatory Considerations

Cholic Acid (CAS 81-25-4) is generally recognized as safe (GRAS) by the FDA for certain applications. Its use in specific therapeutic applications may require additional regulatory approval depending on the jurisdiction and intended use.

8. Future Research Directions

The scientific community anticipates:

• Advanced studies on bile acid-mediated cell signaling pathways
• Exploration of Cholic Acid’s potential in personalized medicine approaches
• Development of novel Cholic Acid-based therapeutics for metabolic disorders

9. Collaborative Opportunities

We invite researchers, pharmaceutical companies, and academic institutions to explore the research potential of Cholic Acid. For inquiries, collaborations, or to discuss how Cholic Acid can benefit your research projects, please contact us at [email protected].

Join us in advancing biological and pharmaceutical research with Cholic Acid – a fundamental bile acid at the intersection of metabolism, signaling, and drug development.