Palmatine Chloride: Potent Alkaloid with Diverse Bioactivity

1. Molecular Identity

• Chemical Name: 5,6-Dihydro-2,3,9,10-tetramethoxydibenzo[a,g]quinolizinium chloride
• CAS Number: 10605-02-4
• Source: Extracted from various plants, including Coptis chinensis and Berberis species

2. Biochemical Significance

Palmatine chloride is a quaternary protoberberine alkaloid with a wide range of pharmacological activities. Its unique molecular structure contributes to its diverse biological effects, making it a compound of significant interest in natural product research and potential therapeutic applications.

3. Key Properties

• Antimicrobial: Exhibits activity against various pathogens
• Anti-inflammatory: Demonstrates potential in modulating inflammatory responses
• Antioxidant: Shows free radical scavenging capabilities
• Metabolic Modulator: Influences glucose and lipid metabolism

4. Potential Research Applications

• Infectious disease studies
• Inflammatory disorder investigations
• Diabetes and metabolic syndrome research
• Neurodegenerative disease studies

5. Current Research Focus

Ongoing studies are investigating Palmatine chloride’s effects on:

• Bacterial and fungal infections
• Inflammatory signaling pathways
• Glucose uptake and insulin sensitivity
• Neuroprotection in cognitive disorders

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing bioavailability and stability
• Developing targeted delivery systems
• Creating synergistic combinations with other bioactive compounds

7. Regulatory Considerations

As a natural alkaloid, Palmatine chloride (CAS 10605-02-4) is primarily used in research settings. Its development for therapeutic applications would require comprehensive safety and efficacy evaluations to meet regulatory standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced studies on mechanisms of action in various diseases
• Exploration of Palmatine’s potential in combination therapies
• Investigation of structure-activity relationships for optimized derivatives

9. Collaborative Opportunities

We invite researchers, pharmaceutical companies, and academic institutions to explore the research potential of Palmatine chloride. For inquiries, collaborations, or to discuss how Palmatine chloride can benefit your research projects, please contact us at [email protected].

Join us in unlocking the full potential of Palmatine chloride – a versatile alkaloid at the forefront of natural product research and innovative therapeutic strategies.