Taurochenodesoxycholic Acid: Specialized Bile Acid for Hepatic and Metabolic Research

1. Molecular Identity

• Chemical Name: 3α,7α-Dihydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide
• CAS Number: 516-35-8
• Source: Naturally occurring bile acid, also synthetically produced

2. Scientific Relevance

Taurochenodesoxycholic acid (TCDCA) is a taurine-conjugated bile acid known for its role in lipid emulsification and regulation of bile acid–dependent pathways. Its structure and biochemical profile make it a valuable compound in studies of hepatic metabolism, intestinal health, and cellular signaling.

3. Key Research Properties

• Facilitates lipid solubilization and absorption in model systems
• Modulates bile acid–activated receptor pathways (e.g., FXR, TGR5)
• Studied for its cytoprotective effects in hepatic environments
• Involved in metabolic signaling and homeostasis

4. Potential Research Applications

• Bile acid metabolism and receptor studies
• Experimental models of hepatic lipid regulation
• Cellular assays in glucose and insulin response research
• Excipient in solubilization systems and absorption enhancement

5. Current Research Topics

Investigations include:

• Mechanisms of bile acid signaling in metabolic pathways
• Interactions with intestinal microbiota and mucosal function
• Regulation of hepatic lipid accumulation in in vitro systems
• Application in delivery platforms for hydrophobic molecules

6. Formulation Insights

Research teams are focused on:

• Enhancing physicochemical stability under diverse lab conditions
• Integrating TCDCA into nanoformulations and micelle systems
• Evaluating co-formulation strategies with other bioactive compounds

7. Compliance and Handling

TCDCA (CAS 516-35-8) is widely used in biochemical and analytical laboratories. Its application in regulated product development requires adherence to applicable safety and material standards, depending on the region and intended use.

8. Future Research Directions

Emerging areas of interest include:

• Structure–activity studies of bile acid–receptor interactions
• Modeling of enterohepatic circulation in lab environments
• Development of bile acid–based carriers for research compounds

9. Collaborative Opportunities

We invite hepatology researchers, metabolic scientists, formulation experts, and academic institutions to explore the potential of Taurochenodesoxycholic acid in their ongoing work. For technical details, research inquiries, or collaboration proposals, please contact us at [email protected].

Discover how TCDCA can support advanced research in bile acid biology, lipid metabolism, and compound delivery science.