Yohimbine hydrochloride: Potent Alpha-2 Adrenergic Antagonist for Advanced Biomedical Research

1. Molecular Identity

• Chemical Name: 17α-Hydroxyyohimban-16α-carboxylic acid methyl ester hydrochloride
• CAS Number: 65-19-0
• Source: Synthetic derivative of yohimbine, an alkaloid found in Pausinystalia yohimbe bark

2. Biochemical Significance

Yohimbine hydrochloride is a potent alpha-2 adrenergic receptor antagonist with diverse pharmacological activities. Its unique molecular structure contributes to its potential applications in treating erectile dysfunction, enhancing fat loss, and modulating central nervous system activity, making it a compound of significant interest in pharmaceutical research and clinical studies.

3. Key Properties of Yohimbine hydrochloride

• Alpha-2 Adrenergic Antagonist: Demonstrates high affinity for alpha-2 receptors
• Vasodilator: Shows potential in improving blood flow
• Lipolytic: Exhibits promise in enhancing fat breakdown
• CNS Stimulant: Indicates efficacy in modulating central nervous system activity

4. Potential Research Applications

• Erectile dysfunction studies
• Weight loss and body composition research
• Anxiety and mood disorder investigations
• Autonomic nervous system function studies

5. Current Research Focus

Ongoing studies are investigating Yohimbine hydrochloride’s effects on:

• Mechanisms of action in erectile function
• Lipolysis and fat mobilization pathways
• Neurochemical modulation in anxiety and depression models
• Interactions with other neurotransmitter systems

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Developing targeted delivery systems for specific applications
• Creating stable formulations with improved bioavailability
• Exploring synergistic combinations with other therapeutic agents

7. Regulatory Considerations

Yohimbine hydrochloride (CAS 65-19-0) is used in research settings and as a prescription medication in some countries. Its development for new therapeutic applications would require comprehensive safety and efficacy evaluations to meet regulatory standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced clinical trials for new indications in mental health
• Exploration of Yohimbine’s potential in combination therapies for metabolic disorders
• Investigation of its long-term effects on cardiovascular and neurological health

9. Collaborative Opportunities

We invite urologists, psychiatrists, endocrinologists, and academic institutions to explore the research potential of Yohimbine hydrochloride. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at [email protected].

Join us in advancing biomedical research with Yohimbine hydrochloride – a powerful alpha-2 adrenergic antagonist at the forefront of pharmaceutical research and therapeutic strategies.