Puerarin: Potent Isoflavone for Advanced Biomedical Research

1. Molecular Identity

• Chemical Name: 7-Hydroxy-3-(4-hydroxyphenyl)-1-benzopyran-4-one 8-β-D-glucopyranoside
• CAS Number: 3681-99-0
• Source: Naturally occurring in Pueraria lobata (Kudzu root) and other Pueraria species

2. Biochemical Significance

Puerarin is a unique isoflavone glycoside with diverse biological activities. Its distinctive molecular structure contributes to its potent antioxidant, cardiovascular, and neuroprotective properties, making it a compound of significant interest in pharmaceutical research and potential therapeutic applications.

3. Key Properties of Puerarin

• Antioxidant: Exhibits strong free radical scavenging activity
• Cardiovascular Protection: Demonstrates potential in improving heart function and circulation
• Neuroprotective: Shows promise in protecting neuronal cells
• Estrogenic Activity: Displays weak phytoestrogenic effects

4. Potential Research Applications

• Cardiovascular disease studies
• Neurodegenerative disorder investigations
• Diabetes and metabolic syndrome research
• Menopause and osteoporosis studies

5. Current Research Focus

Ongoing studies are investigating Puerarin’s effects on:

• Ischemic heart disease and stroke prevention
• Cognitive function and neuroprotection in various brain disorders
• Glucose metabolism and insulin sensitivity
• Bone density and osteoporosis prevention

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing bioavailability through novel delivery systems
• Developing stable formulations for various applications
• Creating synergistic combinations with other bioactive compounds

7. Regulatory Considerations

Puerarin (CAS 3681-99-0) is primarily used in research settings and traditional medicine. Its development for specific therapeutic applications would require comprehensive safety and efficacy evaluations to meet regulatory standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced clinical trials for cardiovascular and neurological indications
• Exploration of Puerarin’s potential in combination therapies
• Investigation of its mechanisms of action at the molecular level

9. Collaborative Opportunities

We invite pharmacologists, neurologists, cardiologists, and academic institutions to explore the research potential of Puerarin. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at [email protected].

Join us in advancing biomedical research with Puerarin – a powerful isoflavone at the forefront of cardiovascular and neuroprotective studies.